Evidence map›Paper›PMID 40632693›Full record

ReviewMedical science monitor : international medical journal of experimental and clinical research2025

Advances in Neuromodulation Techniques for Aphasia Rehabilitation: A Comprehensive Review.

Jiayi Xia, Yeping Chen, Song Pei, Chunlei Shan, Jingjing Zhang, Zhiqing Zhou, Jiali Wu, Yao Lu, Yiyi Chen, Yunjia Chen

Abstract readReview
In one paragraph

Review in Medical science monitor : international medical journal of experimental and clinical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The nonlinear trajectory of post-stroke aphasia recovery.Frontiers in human neuroscience · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiayi XiaClinical Research Centre, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.
Yeping ChenClinical Research Centre, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.
Song PeiDepartment of Rehabilitation Medicine, Renhe Hospital of Baoshan District, Shanghai, China.
Chunlei ShanDepartment of Rehabilitation Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jingjing ZhangDepartment of Rehabilitation Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhiqing ZhouDepartment of Rehabilitation Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiali WuDepartment of Rehabilitation Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yao LuClinical Research Centre, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.
Yiyi ChenClinical Research Centre, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.
Yunjia ChenClinical Research Centre, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aphasia, a language impairment resulting from stroke or neurodegenerative disease, presents complex rehabilitation challenges. Recently, neuromodulation techniques such as transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and mirror neuron system (MNS) therapy have emerged as promising adjuncts to traditional speech-language therapy. This narrative review summarizes current advances in these 3 modalities. tDCS involves low-intensity electrical stimulation to modulate cortical excitability, with evidence supporting its use in post-stroke aphasia (PSA) and primary progressive aphasia (PPA). TMS, a magnetic stimulation technique, provides more precise cortical targeting through low- or high-frequency protocols and emerging paradigms such as intermittent theta-burst stimulation (iTBS). MNS therapy employs behavioral strategies like action observation and imitation to enhance motor-language pathways. The review also discusses the neural mechanisms underlying aphasia recovery, such as cortical reorganization and interhemispheric compensation, and examines the role of advanced tools such as functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in guiding personalized treatment. Future directions include closed-loop stimulation, multimodal integration, and individualized protocols. This article aims to review recent developments in neuromodulation techniques for rehabilitating patients with aphasia, including transcranial direct current stimulation, transcranial magnetic stimulation, and mirror neuron system therapy.

Indexed as

AphasiaHumansMagnetic Resonance ImagingMirror NeuronsStrokeTranscranial Direct Current StimulationTranscranial Magnetic Stimulation

Identifiers

PMID40632693
PMCPMC12257981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.