Evidence map›Paper›PMID 40632662›Full record

ArticleActa obstetricia et gynecologica Scandinavica2025

Improving imiquimod use in cervical high-grade squamous intraepithelial lesions: A qualitative study.

Caroline L P Muntinga, Helena C J Schellekens, Charlotte G J Penders, Hélène van Meir, Gatske M Nieuwenhuyzen-De Boer, Anna J M van de Sande, Heleen J van Beekhuizen, Peggy J de Vos Van Steenwijk, Ruud L M Bekkers, Edith M G van Esch

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In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caroline L P MuntingaDepartment of Gynecology and Obstetrics, Catharina Ziekenhuis Eindhoven, Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0002-2886-3436
Helena C J SchellekensDepartment of Gynecology and Obstetrics, Catharina Ziekenhuis Eindhoven, Eindhoven, The Netherlands.
Charlotte G J PendersDepartment of Gynecology and Obstetrics, Maastricht Universitair Medisch Centrum, Maastricht, The Netherlands.
Hélène van MeirDepartment of Gynecology and Obstetrics, Tergooi Medisch Centrum, Hilversum, The Netherlands.
Gatske M Nieuwenhuyzen-De BoerDepartment of Gynecology and Obstetrics, Albert Schweitzer Ziekenhuis, Dordrecht, The Netherlands.
Anna J M van de SandeDepartment of Gynecologic Oncology, Erasmus MC Cancer Center, University Medical Center, Rotterdam, The Netherlands.
Heleen J van BeekhuizenDepartment of Gynecologic Oncology, Erasmus MC Cancer Center, University Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0001-8899-7412
Peggy J de Vos Van SteenwijkGROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands.
Ruud L M BekkersDepartment of Gynecology and Obstetrics, Catharina Ziekenhuis Eindhoven, Eindhoven, The Netherlands.
Edith M G van EschDepartment of Gynecology and Obstetrics, Catharina Ziekenhuis Eindhoven, Eindhoven, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo investigate patient experiences and satisfaction with imiquimod for cervical high-grade squamous intraepithelial lesions and its side effects, possibly influencing the (dis)continuation of treatment. Secondary objectives include evaluating patient counseling and guidance before and during imiquimod treatment for cervical high-grade squamous intraepithelial lesions by gynecologists and nurse practitioners to improve patient guidance. MATERIAL AND

methodsSemi-structured interviews were conducted with patients treated with imiquimod for cervical high-grade squamous intraepithelial lesions and with healthcare professionals from hospitals in the Netherlands. Interviews were transcribed and transcripts were analyzed using thematic analysis.

resultsA total of 15 patients, 11 of whom finished imiquimod treatment and four who discontinued imiquimod treatment, and six healthcare professionals were interviewed. Three main themes were identified: counseling and side effects, use of imiquimod, and contact moments during treatment. Many patients believed that sharing patient experiences would help in making treatment decisions. Patients discontinued treatment early due to side effects and the mode of application. Detailed information on application methods and side effect severity during counseling is desirable. Healthcare professionals agreed on the factors that need to be addressed during counseling but held different opinions on imiquimod's side effect severity and application methods.

conclusionsAdequate patient counseling on imiquimod treatment, including the possible application methods and potential side effects, along with optimal guidance during treatment, contributes to a better patient experience and reduces the likelihood of early discontinuation of treatment.

Indexed as

AminoquinolinesAntineoplastic AgentsSquamous Intraepithelial Lesions of the CervixUterine Cervical NeoplasmsAdultCounselingFemaleHumansImiquimodInterviews as TopicMiddle AgedNetherlandsPatient SatisfactionQualitative ResearchAminoquinolinesAntineoplastic AgentsImiquimodhuman papillomavirus virusesimiquimodlesions of the cervixsquamous intraepithelial lesions of the cervixuterine cervical dysplasia

Identifiers

PMID40632662
PMCPMC12393992

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.