Evidence map›Paper›PMID 40632655›Full record

ArticleCell reports2025

JAG modulates sepal flatness by regulating cell growth direction, interacts with AS2, and is antagonized by TCP24.

Xi He, Shouling Xu, Avilash Singh Yadav, Ruoyu Liu, Heng Zhou, Yiru Xu, Dan Xiang, Yuhan He, Juan Xu, Adrienne H K Roeder and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xi HeKey Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture, Institute of Nuclear Agricultural Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Shouling XuKey Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture, Institute of Nuclear Agricultural Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China; National Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, China.
Avilash Singh YadavWeill Institute for Cell and Molecular Biology and Section of Plant Biology, School of Integrative Plant Sciences, Cornell University, Ithaca, NY 14853, USA.
Ruoyu LiuKey Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture, Institute of Nuclear Agricultural Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Heng ZhouKey Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture, Institute of Nuclear Agricultural Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Yiru XuKey Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture, Institute of Nuclear Agricultural Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Dan XiangKey Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture, Institute of Nuclear Agricultural Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Yuhan HeDepartment of Horticulture, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Juan XuState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Adrienne H K RoederWeill Institute for Cell and Molecular Biology and Section of Plant Biology, School of Integrative Plant Sciences, Cornell University, Ithaca, NY 14853, USA.
Lilan HongKey Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture, Institute of Nuclear Agricultural Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China. Electronic address: lilanhong@zju.edu.cn.

Funding

Mechanisms of robustness in organogenesis (Equipment Supplement 2023)R01GM134037 · NIGMS · CORNELL UNIVERSITY · PI ROEDER, ADRIENNE H · 2020 to 2023
$1.5M
NIGMS NIH HHS R01 GM134037
6 · The paper itself

Abstract

Flat plant organs are crucial for optimal organ functionality. Polarity establishment and growth coordination between tissues are key factors in maintaining organ flatness. Ectopic ASYMMETRIC LEAVES2 (AS2) expression in the as2-7D mutant has been shown to disrupt growth across cell layers, leading to epidermal buckling in sepals. However, the detailed molecular mechanism remains unclear. Here, we show that mutation of the JAGGED (JAG) gene suppresses buckling of the as2-7D sepal epidermis. Cellular growth analysis reveals that the jag mutant suppresses the sepal epidermal buckling phenotype by altering cellular growth directions to be more parallel with the proximal-distal direction. On the molecular level, JAG physically interacts with AS2. TEOSINTE BRANCHED 1, CYCLOIDEA, AND PCF FAMILY 24 (TCP24) antagonizes JAG in sepal morphogenesis by repressing JAG transcription and inhibiting the AS2-JAG protein interaction. Our study uncovers a complex molecular network involving AS2, JAG, and TCP24 that is critical for generating flat plant organs.

Indexed as

ArabidopsisArabidopsis ProteinsFlowersJagged-1 ProteinTranscription FactorsGene Expression Regulation, PlantMutationPhenotypePlant EpidermisProtein BindingArabidopsis ProteinsJagged-1 ProteinTranscription FactorsArabidopsisAS2CP: Developmental biologyCP: Plantsflatnessgrowth directionJAGmorphogenesissepalTCP24

Identifiers

PMID40632655
PMCPMC12318447

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