Evidence map›Paper›PMID 40632571›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia.

Rui Zhang, Xiaokang Wu, Seho Kim, Brian Kim, Catherine Xie, Devina Gonzalez, Raven Norris, Nicholas Chin, Liang Li, Scott John and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CaBiomolecules · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rui ZhangSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.ORCID 0000-0003-1893-0647
Xiaokang WuSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.
Seho KimSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.ORCID 0000-0003-3859-2665
Brian KimSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.
Catherine XieSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.
Devina GonzalezSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.
Raven NorrisSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.
Nicholas ChinSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.ORCID 0009-0007-8132-0223
Liang LiSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.
Scott JohnDepartment of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Kenneth D PhilipsonDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Michela OttoliaDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Joshua I GoldhaberSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center and Health Sciences University, Los Angeles, CA 90048.ORCID 0000-0001-8413-5719

Funding

Regulation of cellular calcium by cardiac sodium-calcium exchangeR01HL147569 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI GOLDHABER, JOSHUA I, OTTOLIA, MICHELA · 2019 to 2022
$2.6M
Sodium Dependent Inactivation of the Na+-Ca2+ exchange: Relevance to Cardiac FunctionR01HL152296 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO, OTTOLIA, MICHELA · 2021 to 2024
$2.2M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL147569NHLBI NIH HHS R01 HL147569NHLBI NIH HHS R01 HL152296
6 · The paper itself

Abstract

The cardiac sodium-calcium exchanger (NCX1) is a critical regulator of intracellular calcium (Ca) in cardiomyocytes. Although strongly regulated by pH, the role of NCX1 pH sensitivity in cardiac function and intracellular Ca regulation is not understood. We used CRISPR/Cas9 to produce a pH-resistant NCX1 mouse by replacing histidine 165 with alanine (H165A). H165A mice live into adulthood and are fertile. Comparative studies in isolated ventricular myocytes demonstrated that NCX1 current (I

Indexed as

CalciumCytoplasmMyocardial IschemiaMyocytes, CardiacSodium-Calcium ExchangerAnimalsHydrogen-Ion ConcentrationMaleMiceMyocardial Reperfusion InjuryProtonsCalciumNCX1 protein, mouseProtonsSodium-Calcium Exchangeracidosiscalcium transientscardiac ischemia/reperfusionexcitation–contraction couplingsodium–calcium exchange

Identifiers

PMID40632571
PMCPMC12280879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.