Evidence map›Paper›PMID 40632456›Full record

ArticleObesity surgery2025

Effects of Bariatric Surgery on Endothelial Function and Structure in Individuals with Obesity: A Prospective Study.

Xiao Li, Shuo Wang, Lianjie Sun, Ziwei Sun, Ying Xu, Junyi Ren, Haoyong Yu, Xiaodong Han, Wenkun Bai

Abstract read
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In one paragraph

Article in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiao LiZhongshan Hospital, Shanghai, China.
Shuo WangTongji Hospital of Tongji University, Shanghai, China.
Lianjie SunSeoul National University, Seoul, Korea, Republic of.
Ziwei SunShanghai Sixth Peoples Hospital, Shanghai, China.
Ying XuShanghai Sixth Peoples Hospital, Shanghai, China.
Junyi RenShanghai Sixth Peoples Hospital, Shanghai, China.
Haoyong YuShanghai Sixth Peoples Hospital, Shanghai, China. Yuhaoyong111@163.com.
Xiaodong HanShanghai Sixth Peoples Hospital, Shanghai, China. 1830172941@163.com.
Wenkun BaiTongji Hospital of Tongji University, Shanghai, China. baiwenkun@tongji.edu.cn.

Funding

Shanghai Science and Technology Commission 21Y11910900Tongji University Affiliated Tongji Hospital Project GJPY2318, RCQD2401
6 · The paper itself

Abstract

BACKGROUND AND

aimsThis study aimed to investigate the association between obesity indices and endothelial dysfunction, and evaluate the temporal effects of Metabolic and bariatric surgery (MBS)-induced weight loss on vascular endothelial function and structural remodeling.

methodsA total of 224 individuals completed the study before and 1, 3, 6, and 12 months after MBS. Body Mass Index (BMI) and Conicity Index (CI) were used to quantify obesity severity, while Flow-Mediated Dilation (FMD) and Carotid Intima-Media Thickness (cIMT) served as indicators of endothelial function and vascular structural integrity, respectively. The impact of MBS on endothelial function and structure was then evaluated through a longitudinal study.

resultsPreoperative analysis showed a negative linear correlation between FMD and BMI (r = -0.173, p < 0.05). This association was markedly amplified in the abdominal obesity parameter of CI (r = -0.434, p < 0.05). CI gradually decreased at 3, 6, and 12 months after surgery, accompanied by a gradual increase in FMD values, while cIMT did not change until 3 months. Subgroup analysis showed that in diabetic patients, as blood glucose and insulin resistance reduced, FMD gradually recovered and approached normal.

conclusionIndividuals with abdominal obesity exhibit obvious endothelial dysfunction. MBS can effectively achieve sustained weight loss within 12 months, improve endothelial function, and reduce cardiovascular disease risk factors.

Indexed as

Bariatric SurgeryEndothelium, VascularObesity, AbdominalObesity, MorbidAdultBody Mass IndexCarotid Intima-Media ThicknessFemaleHumansInsulin ResistanceLongitudinal StudiesMaleMiddle AgedProspective StudiesTreatment OutcomeVasodilationConicity indexEndothelial functionFlow-mediated dilationMetabolic and bariatric surgeryObesity

Identifiers

PMID40632456

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.