Evidence map›Paper›PMID 40632386›Full record

ReviewCurrent cardiology reports2025

Cardiac Involvement in Eosinophilic Granulomatosis with Polyangiitis.

Mukunthan Srikantharajah, Deepa Gopalan, Harold Wilson-Morkeh, Salman Siddiqui, Stephen P McAdoo, Taryn Youngstein

Abstract readReview
In one paragraph

Review in Current cardiology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Arrhythmias in Autoimmune Diseases: Immune-Mediated Mechanisms and Management.Journal of cardiovascular development and disease · 2026
    Review
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  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mukunthan SrikantharajahVasculitis Centre, Department of Immunology and Inflammation, Imperial College London, London, UK.
Deepa GopalanVasculitis Centre, Department of Imaging Sciences, Imperial College London, London, UK.
Harold Wilson-MorkehVasculitis Centre, National Heart and Lung Institute, Imperial College London, London, UK.
Salman SiddiquiVasculitis Centre, National Heart and Lung Institute, Imperial College London, London, UK.
Stephen P McAdooVasculitis Centre, Department of Immunology and Inflammation, Imperial College London, London, UK.
Taryn YoungsteinVasculitis Centre, National Heart and Lung Institute, Imperial College London, London, UK. t.youngstein@imperial.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review highlights recent advances in the pathophysiology, diagnosis, and treatment of cardiac disease in patients with Eosinophilic granulomatosis with polyangiitis (EGPA). We outline a diagnostic approach to facilitate early identification of affected patients. RECENT

findingsRecent advancements in diagnostic techniques including cardiac magnetic resonance (CMR) have improved recognition of cardiac disease in patients with EGPA. CMR has demonstrated a high prevalence of cardiac abnormalities, even in the absence of clinical symptoms, electrocardiographic or echocardiographic findings. Cardiac disease is a major cause of mortality in patients with EGPA, accounting for around 50% of disease-related deaths. However, due to the lack of standardised screening and diagnostic criteria, the true incidence remains unknown. Systemic immunosuppressive therapy is warranted to prevent acute complications as well as mitigate the long-term impact of chronic inflammation and tissue damage. Given the challenges in early detection and the prognostic significance of cardiac involvement, we recommend including CMR in the baseline evaluation of all EGPA patients at diagnosis.

Indexed as

Churg-Strauss SyndromeGranulomatosis with PolyangiitisHeart DiseasesEchocardiographyElectrocardiographyHumansImmunosuppressive AgentsMagnetic Resonance ImagingMagnetic Resonance Imaging, CinePrognosisImmunosuppressive AgentsCardiac magnetic resonanceCardiovascularEosinophilic granulomatosis with polyangiitisVasculitis

Identifiers

PMID40632386
PMCPMC12241301

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.