ArticleAging clinical and experimental research2025
Individual-level transitions between chronic disease multimorbidity clusters and the risk of five-year mortality in longitudinal cohort of Chinese middle-aged and older adults.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Patterns of multimorbidity, their outcomes and analytical methods for their determination: a systematic review.BMC public health · 2026Pooled it
- An innovative model for integrated traditional Chinese and Western medicine: state-target differentiation and treatment.Science China. Life sciences · 2026Review
- Bridging Population Patterns and Individual Prediction: Framework for Prospective Multimorbidity Study.JMIR medical informatics · 2026Article
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4 authors.
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Abstract
backgroundWe aimed to trace individual's transition between multimorbidity clusters and examine the addictive and compounding effects of transition trajectories, chronic disease accumulation, and five-year all-cause mortality.
methodsParticipants from the China Health and Retirement Longitudinal Study (2011-2020) were included (N = 8988). Latent class analyses, Cox proportional hazard models, and restricted cubic splines were used to examine the associations.
resultsFive clusters were identified: osteoarticular, cardiometabolic, multisystem, digestive, and respiratory. Participants who had multisystem multimorbidity and further developed respiratory diseases had mortality risk 9 times higher than the healthy participants (HR:9.04; 95% CI 3.44-23.73). For participants experienced prolonged cardiometabolic multimorbidity, the mortality risk increased by 26% with each additional chronic disease and by 38% with each additional body system affected between 2011 and 2015.
conclusionSubsequent interventions should prioritize those who experienced prolonged multi-system multimorbidity, developed respiratory diseases from existing multi-system conditions, or developed additional chronic diseases from existing cardiometabolic multimorbidity.
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