ArticleAging clinical and experimental research2025
Association between high-sensitivity C-reactive protein, cystatin C and all-cause mortality in middle-aged and elderly participants with sarcopenia.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Divergent associations of social isolation with body composition in Chinese middle-aged and older adults.Population health metrics · 2026Observational
- The Role of hs-CRP and Systemic Immune-Inflammation Index in Sarcopenia and Sarcopenic Obesity in Young Populations: Results from the National Health and Nutrition Examination Survey 2015-2018.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Association Between Serum High Sensitivity C-Reactive Protein Levels and Low Muscle Strength Among Korean Adults.Nutrients · 2025Article
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7 authors.
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Abstract
backgroundHigh-sensitivity C-reactive protein (hs-CRP) and cystatin C (CysC), which associate with prognosis, are widely used indicators for inflammation and kidney function respectively in clinical practice.
aimsThis study aims to determine whether elevated hs-CRP and CysC concentrations are associated with all-cause mortality in middle-aged and elderly participants with sarcopenia.
methodsThis was a retrospective study which included 612 individuals with sarcopenia from a Chinese cohort. Concentrations of hs-CRP and CysC were divided into three groups (tertiles). Cox regression models were utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause mortality. Combined effects were calculated by dividing two indicators into four groups based on cutoffs of high risk. Subgroup analyses were performed to better stratify analyses and show the interaction of variables for associations between hs-CRP/CysC and mortality.
resultsThe mean age of the participants was 70.88 (6.61) years, among which 40.03% were male. During follow-up 130 death cases occurred and mortality rate was 21.2%. Hs-CRP and CysC were prominently associated with all-cause mortality as continuous variables. Hs-CRP also manifested great capability of predicting mortality as categorical variable. When both indicators were higher than cutoffs, the combined effect was positive in Model3 (HR = 2.26, 95%CI: 1.01-5.07). Two biomarkers showed significant associations among subgroup population who were male and > 75 years old. CysC had an linear association with mortality while hs-CRP not.
conclusionHs-CRP and CysC might be useful indicators for the prognosis of middle-aged and elderly participants with sarcopenia. The combined effects of two indicators predicted mortality well.
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