ArticleJournal of molecular histology2025
Long non-coding RNA MINCR silencing contributes to suppressed gemcitabine resistance in bladder cancer by blocking the ZEB1/PHGDH axis through microRNA-876-5p up-regulation.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- From molecular networks to translational intervention: current progress in the mechanisms of gemcitabine resistance in bladder cancer.Frontiers in immunology · 2026Review
- Regulatory roles of LncRNAs in colorectal cancer immune evasion: current concepts and future perspectives.Discover oncology · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Long non-coding RNA MINCR performs a tumor-promoting role in various cancers. Accordingly, this research analyzed whether MINCR exerted tumor-promoting effects and facilitated gemcitabine (GEM) resistance in BC. MINCR, microRNA (miR)-876-5p, ZEB1, and PHGDH expression was detected in BC tissues and cells. Following the construction of GEM-resistant cells, MINCR expression was examined with RT-qPCR. Gain- and loss-of-function assays were conducted in GEM-resistant cells, followed by the measurement of cell proliferation, invasion, and apoptosis. The relationships among MINCR, miR-876-5p, and ZEB1 were assessed with dual-luciferase and RIP assays. Subcutaneous tumor formation in nude mice was conducted for in vivo corroboration. MINCR was up-regulated in BC tissues and cells and GEM-resistant BC cells. miR-876-5p expression was poor and ZEB1 and PHGDH expression was abundant in BC tissues. Mechanistically, MINCR enhanced ZEB1 expression in BC cells via competitive binding to miR-876-5p, and ectopic ZEB1 induced PHGDH up-regulation. MINCR silencing diminished proliferation and invasion while accelerating apoptosis in GEM-resistant BC cells, which was further advanced by miR-876-5p overexpression but nullified by ZEB1 overexpression. Meanwhile, MINCR silencing or miR-876-5p overexpression synergized with GEM to depress BC growth in vivo. MINCR silencing impedes GEM resistance in BC through the miR-876-5p/ZEB1/PHGDH axis.
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Registered trials
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