Evidence map›Paper›PMID 40632324›Full record

ArticleMolecular biology reports2025

Aggressive nodular melanoma: case report with an unusual BRAF mutation.

Sanae El Bardai, Fatima El Agy, Fatima Zahra Mernissi, Dounia Kamal, Layla Tahiri Elousrouti, Laila Chbani, Nawal Hammas

Abstract readCase Reports
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In one paragraph

Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sanae El BardaiHigh Institute of Nursing Professions and Health Techniques, Fez, Morocco. souina1974@gmail.com.
Fatima El AgyBiomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdallah University, Fez, Morocco.
Fatima Zahra MernissiDepartment of Dermatology, Hassan II University Hospital, Fez, Morocco.
Dounia KamalDepartment of Maxillofacial Surgery, Hassan II University Hospital, Fez, Morocco.
Layla Tahiri ElousroutiBiomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdallah University, Fez, Morocco.
Laila ChbaniBiomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdallah University, Fez, Morocco.
Nawal HammasBiomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdallah University, Fez, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNodular melanoma (NM) is considered one of the most aggressive forms of skin cancer, accounting for approximately 10-15% of all melanoma cases. It tends to grow quickly and spread deeper into the skin's layers, providing fewer opportunities for early detection. NM often carries a poor prognosis due to local invasion and frequent distant metastases. BRAF mutations are frequently found in melanoma, with the most common mutation being a single-point mutation at codon 600 (typically V600E). CASE PRESENTATION: We report a case of aggressive jugal nodular melanoma harboring an unusual BRAF mutation, C. 1789_1790 CT>TC.

methodsGenomic DNA was extracted from formalin-fixed paraffin-embedded (FFPE) tumor tissue. Sanger sequencing was employed to analyze exon 15 of the BRAF gene. The mutation was validated by bidirectional sequencing and interpreted using reference databases.

resultsThe identified BRAF mutation, c.1789_1790CT>TC, has been rarely reported in the literature. It results in a non-canonical amino acid substitution, potentially affecting kinase activity and therapeutic response.

conclusionThis case underscores the clinical and molecular heterogeneity of nodular melanoma and highlights the importance of comprehensive BRAF mutation screening beyond the common V600E variant.

Indexed as

MelanomaProto-Oncogene Proteins B-rafSkin NeoplasmsFemaleHumansMaleMiddle AgedMutationBRAF protein, humanProto-Oncogene Proteins B-rafBRAFC. 1789_1790 CT > TCMelanomaNodular

Identifiers

PMID40632324

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