ArticleGlobal spine journal2025
Osteoporosis in Adult Patients Undergoing Spinal Reconstructive Surgery: Associated Complications and Management.
Article in Global spine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Understanding the Research Needs and Educational Methods of Surgeons to Help Guide Future Spine Deformity Research: A Survey of AO Spine Members.Global spine journal · 2026Article
- Impact of Preoperative Teriparatide Use on Proximal Junctional Kyphosis Prevention in Osteopenic/Osteoporotic Patients Undergoing Adult Spinal Deformity Surgery: A Propensity Score-Matched Study.Journal of clinical medicine · 2026Article
- Biologic immunomodulators and spinal fusion: evidence, mechanisms, and perioperative considerations.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Sequential Versus Step-Therapy Approaches for Osteoporosis Management in Orthopedic Subspecialties.Current osteoporosis reports · 2026Review
- Dual-targeted hybrid nanovesicles coordinated bone-muscle regeneration via regulating the DUSP4/p38 MAPK pathway to reverse osteosarcopenia.Journal of nanobiotechnology · 2026Article
- Biomechanical Analysis Comparison of Different Cervical Posterior Screw Fixation Techniques: A Finite Element Study.Neurospine · 2026Article
- Therapeutic Approaches for Enhancing Spinal Fusion in Low Back Pain: A Review With a Focus on the Elderly.JOR spine · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Study DesignLiterature review.ObjectivesTo provide an overview of the complications associated with and management strategies for adult patients with osteoporosis requiring spinal reconstructive surgery. Emphasis will be placed on screening, diagnosis, and perioperative medical and surgical management of these patients.MethodsA review of the literature was performed for studies examining osteoporosis in adult patients undergoing spine surgery, associated complications, treatment and prevention methodologies.ResultsThe reported incidence of osteoporosis in adult patients undergoing spinal reconstructive surgery was found to be 10% - 50%, whereas the incidence of osteopenia was 41.4% - 58.6%. DEXA scan is the most widely used modality for assessing bone mineral density (BMD) despite its limitations. Quantitative CT has been found to be the most optimal method for measuring BMD in the spine, yet, its availability is limited. Opportunistic CT scan-based Hounsfield Units (CTHU) have been found to correlate with osteoporosis and osteopenia, instrumentation loosening, proximal and distal junctional kyphosis, and pseudarthrosis. Patients treated with Teriparatide preoperatively and postoperatively were found to have a decreased rate of pseudarthrosis, screw loosening, and reoperation. Modifying surgical techniques can also improve outcomes. Such strategies could involve vertebral cement augmentation, iliac fixation in long constructs to the sacrum, and utilizing longer constructs when addressing spinal deformity or spinal instability.ConclusionsThe incidence of osteoporosis in patients undergoing spinal reconstruction is high. Appropriate preoperative and postoperative medical treatment can result in lower rates of adverse events related to osteoporosis. Surgical treatment and fixation can also be modified to account for suboptimal bone health.
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