Evidence map›Paper›PMID 40632265›Full record

ReviewActa neurochirurgica. Supplement2025

Epidemiology and Aetiology of Cerebral Cavernous Malformations.

Hiroki Hongo, Satoru Miyawaki, Nobuhito Saito

Abstract readReview
PubMed Publisher
In one paragraph

Review in Acta neurochirurgica. Supplement, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hiroki HongoDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. hongoh-nsu@h.u-tokyo.ac.jp.
Satoru MiyawakiDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Nobuhito SaitoDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral cavernous malformations (CCMs) are vascular anomalies affecting the central nervous system in up to 0.5% of the population. These lesions are characterised by thin-walled, dilated blood vessels that are susceptible to haemorrhage. They can cause several symptoms, such as epileptic seizures, haemorrhagic strokes, and focal neurological deficits. Clinical studies have revealed the epidemiology and natural history of CCMs. Human genetic studies have identified CCM1, CCM2, and CCM3 as established driver genes, and more recently, PIK3CA and MAP3K3 have been identified as additional potential driver genes. Moreover, on the basis of genetic information, animal studies have developed model organisms, including murine models, that highly recapitulate human CCMs, facilitating the elucidation of molecular mechanisms. This article provides a brief overview of the epidemiology and aetiology of CCMs.

Indexed as

Hemangioma, Cavernous, Central Nervous SystemAnimalsCarrier ProteinsDisease Models, AnimalHumansKRIT1 ProteinProto-Oncogene ProteinsCarrier ProteinsCCM2 protein, humanKRIT1 ProteinKRIT1 protein, humanProto-Oncogene ProteinsAetiologyCerebral cavernous malformationDevelopmental venous anomalyEpidemiologyGenetic mutationNatural history

Identifiers

PMID40632265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.