Evidence map›Paper›PMID 40632263›Full record

ArticleActa neurochirurgica. Supplement2025

ADC Threshold Indicating the Ischemic Region for Predicting Efficacy in Thrombectomy.

Hideyuki Ishihara, Fumiaki Oka, Takuma Nishimoto, Masatoshi Yamane, Kazutaka Sugimoto, Hirokazu Sadahiro

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Article in Acta neurochirurgica. Supplement, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Hideyuki IshiharaDepartment of Neurosurgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan. hishi@yamaguchi-u.ac.jp.ORCID https://orcid.org/0000-0002-0208-2412
Fumiaki OkaDepartment of Neurosurgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Takuma NishimotoDepartment of Neurosurgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Masatoshi YamaneDepartment of Radiology, Yamaguchi University Hospital, Ube, Yamaguchi, Japan.
Kazutaka SugimotoDepartment of Neurosurgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Hirokazu SadahiroDepartment of Neurosurgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe effectiveness of endovascular thrombectomy (EVT) has been proven in patients with large cerebral infarction. However, the size of the ischemic region before treatment is a significant factor in the outcome, and the optimal method for the evaluation of this region is uncertain. The goal of this study was to investigate apparent diffusion coefficient (ADC) values as a basis for an assessment of the ischemic region before treatment.

methodsA retrospective study was performed in 48 consecutive patients who underwent EVT for acute large vessel occlusion (LVO) with Alberta Stroke Program Early Computed Tomography Score (ASPECTS) ≤5 from 2014 to 2022. Associations of clinical characteristics and ADC-related ischemic region volumes with a favorable outcome (modified Rankin Scale (mRS) 0-3 at 90 days) were examined.

resultsThe 48 patients had a median age of 78 years and a median NIHSS score of 23 at admission. Occlusion sites were the internal carotid artery (46%), M1 segment (46%), and M2 segment (8%). Specifically, 18 cases (38%) were mRS 0-3 and 30 (62%) mRS 4-6 at 90 days. In receiver operating characteristic (ROC) analysis, an ischemic region defined as a volume with an ADC < 540 (ADC

conclusionsEarlier reperfusion and a smaller ischemic region defined by ADC

Indexed as

Brain IschemiaDiffusion Magnetic Resonance ImagingEndovascular ProceduresIschemic StrokeThrombectomyAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesROC CurveTreatment OutcomeApparent diffusion coefficientDiffusion-weighted imageEndovascular treatmentIschemic stroke

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PMID40632263

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