ArticleArchives of orthopaedic and trauma surgery2025
Multiple sclerosis is associated with increased shoulder dislocations and aseptic loosening following reverse shoulder arthroplasty: a propensity matched analysis.
Article in Archives of orthopaedic and trauma surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMultiple sclerosis (MS) is a chronic neurological condition characterized by muscle spasticity, which may influence the outcomes of reverse shoulder arthroplasty (RSA) for glenohumeral osteoarthritis or proximal humerus fractures. It is unclear whether implant complications and revision rates are increased in patients with MS. The aim was to compare 2-year implant complications and 90- day costs in MS patients undergoing RSA.
methodsA retrospective analysis was performed using the PearlDiver database (2010-2022). MS patients (N = 764) who underwent RSA either for glenohumeral osteoarthritis or proximal humerus fractures were identified and matched to patients without MS (N = 3,682) in a 1:5 ratio by age, sex, and comorbidities. Two-year implant complications, including shoulder dislocations, aseptic loosenings, periprosthetic joint infections (PJIs), periprosthetic fractures, and all-cause shoulder arthroplasty revisions, were compared between the two groups using multivariable logistic regressions. Costs were evaluated over a 90 day episode of care interval. P values < 0.05 were significant.
resultsThe proportion of patients who underwent RSA for proximal humerus fracture was not different between patients with and without MS (12.4% vs. 15.1%; P = 0.063). Patients had no difference in overall comorbidity burden (ECI: 8.1 vs. 8.0; P = 0.39). At 2 years, MS patients were associated with significantly higher rates and odds of shoulder dislocations (OR: 1.94, P = 0.006) and aseptic loosenings (OR: 1.93, P = 0.044). There was no significant difference in all-cause revisions (OR: 1.39, P = 0.183), PJIs (OR: 0.72, P = 0.326), or periprosthetic fractures (OR: 1.20, P = 0.773) compared to controls. Patients with MS incurred significantly higher 90 day episode of care costs: $11,437 vs. $10,321; P = 0.0002.
conclusionsMS patients undergoing RSA were associated with significantly higher rates of shoulder dislocations and aseptic loosening compared to controls. Additionally, MS patients incurred significantly higher 90-day episode of care costs. These findings underscore the need for careful perioperative planning and long-term monitoring in MS patients undergoing RSA. LEVEL OF EVIDENCE: III.
Indexed as
Identifiers
40632230What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.