ArticleEuropean journal of nuclear medicine and molecular imaging2025
Molecular imaging based biophysical changes of striatum closely associated with cognitive impairment in childhood self-limited epilepsy with centrotemporal spikes.
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to investigate the functional role of striatum in cognitive impairment of self-limited epilepsy with centrotemporal spikes (SeLECTS) patients using
methodsForty-three patients with SeLECTS (24 typical and 19 atypical) who underwent [
resultsCompared with typical SeLECTS and control group, atypical SeLECTS patients had inferior intelligence quotient (IQ). PET image analysis presented significantly reduced SUVR in bilateral putamen and pallidum of SeLECTS patients. Specifically, atypical SeLECTS had the lowest SUVR of bilateral putamen and pallidum. MRI image analysis showed markedly reduced volume of left putamen and bilateral pallidum in atypical SeLECTS and enlarged volume of left pallidum in typical SeLECTS. Correlation analysis showed that altered SUVR and volume in lenticula were significantly associated with cognitive impairment.
conclusionThis study presented the first imaging findings that cognitive impairment in both atypical and typical SeLECTS patients is highly correlated with glucose metabolism and volume of lenticula, especially in the pallidum, providing further understanding for cognitive impairment of SeLECTS.
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