ArticleEuropean journal of nuclear medicine and molecular imaging2025
ImmunoPET imaging of c-Met using a nanobody-based tracer [
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- IDH-genotype-linked kinase rewiring accompanies enhanced therapeutic response to dual-drug ferritin nanocages in high-grade glioma.Materials today. Bio · 2026Article
- A single-arm prospective phase I trial of 68Ga-PFBC01 PET/CT for multiple myeloma B cell maturation antigen imaging.The Journal of clinical investigation · 2026Article
- Specific PET Imaging for Precision Management of Lung Cancer: Advances, Clinical Translation and Future Directions.Chemical & biomedical imaging · 2026Review
- Molecular Imaging in Pancreatic Cancer: Current Applications and Future Perspectives.Pharmaceuticals (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposePancreatic ductal adenocarcinoma (PDAC) is the most prevalent form of pancreatic cancer, with high malignancy and poor prognosis. The cellular mesenchymal-epithelial transition factor (c-Met) is overexpressed in 84% of PDAC and plays a critical role in tumor progression, which is closely associated with poor patient outcomes. In this study, a new
methodsThe Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) data were utilized to assess MET expression and overall survival in patients with different cancers. By immunizing an alpaca with recombinant human c-Met, three clones of nanobodies were screened, and the binding affinity was tested by bio-layer interferometry (BLI). The binding epitope of the nanobodies and c-Met was predicted by AlphaFold3. c-Met expression in human PDAC cell lines was evaluated using western blot, flow cytometry, and confocal microscopy. NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) chelator was used to label the nanobodies with
resultsBased on TCGA and GTEx data, MET expression in pancreatic adenocarcinoma (PAAD) is significantly higher than that in normal tissues (P < 0.001). Patients with high MET expression have lower overall survival rates than those with low MET expression. c-Met expression was the highest in BXPC-3 cells but the lowest in MIA PaCa-2 cells, which were set as the positive and negative models respectively. PFCM01 was screened and selected with an excellent binding property with the K
conclusions[
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