ArticleAnnals of surgical oncology2025
Preoperative Systemic Immune-Inflammatory Index Predicts Occult Nodal Disease in Clinically Node-Negative Intrahepatic Cholangiocarcinoma.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Occult Nodal Disease in Gallbladder Cancer: An International Multi-institutional Analysis and Preoperative Risk Stratification.Annals of surgical oncology · 2026Article
- ASO Author Reflections: Closing the Staging Gap in Gallbladder Cancer: Preoperative Risk Enrichment for Occult Nodal Disease.Annals of surgical oncology · 2026Article
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28 authors.
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Abstract
backgroundAccurate preoperative diagnosis of nodal status in intrahepatic cholangiocarcinoma (ICC) remains challenging. The objective of the current study was to determine if the systemic immune-inflammatory index (SII) was associated with occult nodal disease (OND) among cN0 patients undergoing resection for ICC.
methodsPatients who underwent curative resection for ICC were identified from an international multi-institutional database. A multivariable logistic regression model was used to assess the relationship between SII and OND.
resultsAmong 490 patients who underwent curative resection with lymph node dissection (LND) for cN0 ICC, 135 (27.6%) had OND. Among these individuals, high SII (≥738.4) was independently associated with OND (odds ratio [OR], 1.85, 95% confidence interval [CI], 1.18-2.92). This association was consistent even among patients with cT1aN0M0 disease (OR, 1.85; 95% CI, 1.19-2.88). Interestingly, among patients with high SII and N0/Nx disease, individuals whose total number of lymph nodes examined (TLNE) was fewer than six had worse 3-year recurrence-free survival (RFS) than patients with a TLNE of six or more (38.8% vs 74.0%; p = 0.002). In contrast, RFS did not differ among patients with low SII and N0/Nx disease (TLNE <6 [49.1%] vs ≥6 [62.4%]; p = 0.099).
conclusionsHigh SII was an independent predictor of OND, even among patients with early-stage disease, suggesting that incorporating SII into preoperative risk assessment may refine staging and guide treatment strategies including the need for neoadjuvant therapy as well as the extent and adequacy of LND.
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