ArticleJapanese journal of radiology2025
Whole-tumor histogram analysis of synthetic MRI relaxation maps for nasopharyngeal carcinoma: correlations with histopathologic components.
Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo explore the correlation between the histogram parameters from synthetic magnetic resonance imaging (syMRI) relaxation maps and histopathologic components in nasopharyngeal carcinoma (NPC).
methodsEighty NPC patients who performed syMRI examination were retrospectively enrolled between September 2020 to June 2022, and whole-tumor histogram parameters from syMRI relaxation maps (T1, T2, PD) were obtained. The relationship between histogram parameters and histopathologic components were investigated using the Spearman correlation coefficient, and stepwise multiple linear regression analysis was used to select the independent factors. Kaplan-Meier analysis and log-rank test were performed to compare differences in progression-free survival between low and high histopathologic components.
resultsThe histogram parameters from T1 and T2 maps were significantly correlated with histopathologic components, including cellular, stromal, nuclear, cytoplasmic fractions, and nuclear/cytoplasmic (N/C) ratio (P < 0.007), whereas no significant correlations were found between any histogram parameters from PD and histopathologic components (P > 0.007). T1
conclusionsThe syMRI quantitative parameters were significantly correlated with histopathologic components in NPC, which aids in adjusting treatment strategies and predicting prognosis at an early stage.
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