Evidence map›Paper›PMID 40632184›Full record

ArticleEuropean journal of pediatrics2025

Predictive value of lymphocyte-to-C-reactive protein ratio for predicting initial and repeated intravenous immunoglobulin resistance in a large cohort of Kawasaki disease: a prospective cohort study.

Yaru Cui, Jing Zhao, Pingting Ye, Hongyu Duan, Xiaoliang Liu, Kaiyu Zhou, Yimin Hua, Fan Ma, Jinhui Li, Shuran Shao and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yaru Cui *Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Jing Zhao *Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Pingting YeThe First People's Hospital of Shuangliu District, Chengdu, Sichuan, China.
Hongyu DuanKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Xiaoliang LiuKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Kaiyu ZhouKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Yimin HuaKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Fan MaKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Jinhui LiKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Shuran ShaoKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. 36882191@qq.com.
Chuan WangKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. wangchuan1308@163.com.

Funding

Key research and development project of Chengdu Science and Technology Bureau 2024-YF05-00237-SNNational Key Research and Development Program of China No. 2022YFC2703902National Natural Science Foundation of China No. 82370236Natural Science Foundation of Sichuan Province 2024NSFSC1711Natural Science Foundation of Sichuan Province 2024YFFK0078Natural Science Foundation of Sichuan Province 2024YFFK0272Natural Science Foundation of Sichuan Province 2025ZNSFSC0705
6 · The paper itself

Abstract

Lmphocyte-to-C-reactive protein ratio (LCR) has tremendous predictive power for diseases with similar pathogenesis to Kawasaki disease (KD). The evidence on the prognostic value of LCR for IVIG resistance, especially for repeated IVIG resistance in KD, remains scarce. We conducted a prospective cohort study comprising 1607 individuals with KD to evaluate the predictive value of LCR for both the initial and repeated IVIG resistance. A comparison was made between the initial/repeated IVIG-resistance group and the initial/repeated IVIG-response group. We found that LCR was markedly reduced in both initial and repeated IVIG non-responders and was an independent risk factor for forecasting both initial and repeated IVIG resistance in KD. The optimal cut-off values of LCR for predicting initial and repeated IVIG resistance were 0.042 × 10

Indexed as

C-Reactive ProteinDrug ResistanceImmunoglobulins, IntravenousLymphocytesMucocutaneous Lymph Node SyndromeBiomarkersChildChild, PreschoolFemaleHumansInfantMalePredictive Value of TestsPrognosisProspective StudiesBiomarkersC-Reactive ProteinImmunoglobulins, IntravenousIntravenous immunoglobulin resistanceKawasaki diseaseLymphocyte-to-C-reactive protein ratioPrediction

Identifiers

PMID40632184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.