SynthesisArchives of gynecology and obstetrics2025
Risk factors for adverse pregnancy outcomes in systemic lupus erythematosus: a meta-analysis and systemic review.
Synthesis in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Asia Pacific League of Associations for Rheumatology (APLAR) Consensus Statements for the Management of Reproductive Issues in Autoimmune Rheumatic Diseases.International journal of rheumatic diseases · 2026Pooled it
- Dual BAFF/APRIL inhibition with telitacicept in systemic lupus erythematosus and IgA nephropathy: pharmacological rationale, clinical efficacy, and safety on female fertility preservation.Frontiers in pharmacology · 2026Pooled it
- Patient-reported reproductive concerns and care needs among women with systemic lupus erythematosus: a descriptive qualitative study using patient journey mapping.Rheumatology international · 2026Article
- Predictors of adverse pregnancy outcomes in systemic lupus erythematosus: A retrospective cohort study.Clinical rheumatology · 2026Article
- Hydroxychloroquine withdrawal triggers pregnancy-associated pulmonary arterial hypertension in systemic lupus erythematosus: a case report and exploration of the Complement-EndMT axis.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSystemic lupus erythematosus (SLE) is a prominent autoimmune disease highly linked to adverse pregnancy outcomes (APOs). Previous research on the risk factors for APOs in SLE pregnancies has been limited by regional constraints or inadequate sample sizes. Comprehensive systematic reviews on this topic remain scarce. To address these research gaps, we conducted a rigorous meta-analysis and systematic review to elucidate the risk factors for APOs in SLE pregnancies.
methodsPubMed, Embase, Web of Science, and the Cochrane Library systematically searched for articles on risk factors for APOs in SLE pregnancy from initiation to March 25, 2025. Pooled odds ratios (ORs) were calculated using fixed-effect or random-effects models based on heterogeneity (I
resultsA total of 43 studies were reviewed. Patients with hypertension, lupus nephritis (LN), high disease activity, low complements, and antiphospholipid syndrome (APS)/positive antiphospholipid antibodies (aPL) were identified as having a higher risk for adverse pregnancy outcomes (APOs). Risk factors for preterm birth included LN, hypertension, disease flares, high disease activity, and APS/aPL. Risk factors for pregnancy loss included APS/aPL, low complements, disease flares, LN, hypertension, thrombocytopenia, and high disease activity. LN was also associated with an increased risk of intrauterine growth restriction and low birth weight.
conclusionsThis study identified risk factors for APOs in SLE pregnancies. These findings may support early identification of high-risk patients and guide timely interventions to improve maternal and fetal outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.