ReviewThe ISME journal2025
Understanding prokaryotic adaptation through advanced DNA methylation detection techniques.
Review in The ISME journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Challenges and Technological Strategies to Enhance Probiotic Viability in Non-Dairy Food Matrices.Molecules (Basel, Switzerland) · 2026Review
- Epigenetic regulation in prokaryotes: transcriptional and phenotypic outcomes of DNA methyltransferase activity.FEMS microbiology reviews · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation, a versatile epigenetic modification in prokaryotes, is a crucial regulator of various biological activities, such as genome defence, gene expression, and DNA repair. The most common DNA methylation form in prokaryotes is N6-methyladenine, where a methyl group is added to the adenine. Orphan and restriction-modification system methylases constitute the main methylation systems in prokaryotes. Prokaryotes can adapt to environmental fluctuations through orphan methylase regulation and phase variation of restriction-modification systems, which generate diversified methylomes that modulate the expression of genes. Modern sequencing techniques, including single-molecule real-time sequencing and Nanopore sequencing, enable the characterization of several methylation patterns simultaneously and facilitate the study of prokaryotic epigenomics. This review introduces the prokaryotic DNA methylation systems and prokaryotic adaptation through DNA methylation. Finally, we summarize the current sequencing techniques capable of characterizing methylation forms applicable to prokaryotes and their future perspectives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.