Evidence map›Paper›PMID 40632103›Full record

ArticleACS chemical biology2025

Target-Responsive DNA Hydrogels with Encapsulation and Release Properties Using Programmable CRISPR-Cas12a.

Ram J Tharu, Emmett Hanson, Mehmet V Yigit

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Effects of NBioconjugate chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ram J TharuDepartment of Chemistry, University at Albany, State University of New York, 1400 Washington Avenue, Albany, New York 12222, United States.
Emmett HansonDepartment of Chemistry, University at Albany, State University of New York, 1400 Washington Avenue, Albany, New York 12222, United States.
Mehmet V YigitDepartment of Chemistry, University at Albany, State University of New York, 1400 Washington Avenue, Albany, New York 12222, United States.ORCID 0000-0002-4349-3701

Funding

DNA nanotechnology and synthetic biology for AI-supported detection and precision therapeuticsR35GM156250 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Mehmet Veysel Yigit · 2025 to 2026
$779k
NIGMS NIH HHS R35 GM156250
6 · The paper itself

Abstract

We report the development of a DNA hydrogel that disassembles and releases its payload in response to a target of interest. The DNA hydrogel is assembled from Y-shaped DNA motifs with polyA domains and cross-linked

Indexed as

CRISPR-Associated ProteinsCRISPR-Cas SystemsDNAEndodeoxyribonucleasesHydrogelsBacterial ProteinsSalmonella typhimuriumBacterial ProteinsCas12a proteinCRISPR-Associated ProteinsDNAEndodeoxyribonucleasesHydrogels

Identifiers

PMID40632103
PMCPMC12281480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.