ArticleJASA express letters2025
Early fiber development in human vocal folds: An in vitro pilot study.
Article in JASA express letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
When stretch and vibration are applied, human vocal folds develop from an isotropic gel-like structure to a layered structure with specific fiber direction. A human vocal fold fibroblast cell line was used to seed polyurethane foams that were cultured in media and subjected to a variety of mechanical conditioning regimens over a 3-week period. A bioreactor mimicked forces experienced by the human vocal folds to develop a vocal ligament. Fiber orientation was studied qualitatively for combinations of strain and vibration. While collagen type 1 fibers were randomly organized under static conditions, a combination of vibration and strain produced some fiber orientation.
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