Evidence map›Paper›PMID 40631986›Full record

ArticleAntimicrobial agents and chemotherapy2025

NorA and Tet38 efflux pumps enable

Q C Truong-Bolduc, Y Wang, B G Lawton, J J Zweifach, G M McDevitt, Y El Abdellaoui, H Brown Harding, L M Yonker, L G Rahme, J M Vyas and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Q C Truong-BolducInfectious Diseases Division and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-3275-4360
Y WangInfectious Diseases Division and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
B G LawtonDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
J J ZweifachDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
G M McDevittDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Y El AbdellaouiDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
H Brown HardingInfectious Diseases Division and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
L M YonkerDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1711-8227
L G RahmeDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
J M VyasInfectious Diseases Division and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
D C HooperInfectious Diseases Division and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-1444-9939

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
Defining neutrophil pathobiology in pediatric Long COVIDR01HL173059 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Lael Yonker · 2024 to 2026
$2.4M
NHLBI NIH HHS R01 HL173059NIAID NIH HHS P01 AI083214NIH HHS P01-AI083214
6 · The paper itself

Abstract

Efflux pumps play multiple roles in bacterial physiology, environmental adaptation, and antibiotic resistance. Early cystic fibrosis (CF) airway infections start with

Indexed as

Anti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsCystic FibrosisPseudomonas aeruginosaPseudomonas InfectionsStaphylococcus aureusCoinfectionHumansMicrobial Sensitivity TestsSputumStaphylococcal InfectionsAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsNorA protein, Staphylococcuscystic fibrosisefflux pumpNorAP. aeruginosaS. aureusTet38

Identifiers

PMID40631986
PMCPMC12326990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.