ArticleAntimicrobial agents and chemotherapy2025
Distribution of acyclovir in central nervous system compartments: a porcine pharmacokinetic model.
Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Antibacterial therapy in central nervous system infections - breakpoints versus minimal inhibitory concentrations related to body fluid levels.Infection · 2026Review
- Effects of bolus injection rate on the pharmacodynamics and pharmacokinetics of propofol, etomidate and sufentanil in rats.Frontiers in veterinary science · 2025Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herpes simplex virus (HSV) encephalitis is a severe infection with high mortality and neurological sequelae if untreated. Intravenous acyclovir (ACV) is the standard treatment, but its central nervous system (CNS) penetration is not fully understood. To evaluate the distribution of ACV in various CNS compartments in a porcine pharmacokinetic model, 12 female pigs were divided into two groups: group I receiving a single ACV dose (10 mg/kg) and group II receiving three doses over 24 h. Microdialysis sampled unbound ACV concentrations in cortical and subcortical extracellular fluid (ECF), ventricular cerebrospinal fluid (CSF), and cisternal CSF. The ACV target concentration was defined as peak concentration (
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