Evidence map›Paper›PMID 40631898›Full record

ArticlemBio2025

Macrophage phagocytosis of human norovirus-infected cells in an

Ngan Fung Li, Sue E Crawford, Sydney R Mittiga, Cristian Coarfa, Hoa Nguyen-Phuc, Budi Utama, Sarah E Blutt, Sasirekha Ramani, Mary K Estes

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ngan Fung LiDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-1204-5567
Sue E CrawfordDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-8113-3806
Sydney R MittigaDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0009-0004-8428-2718
Cristian CoarfaDan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-4183-4939
Hoa Nguyen-PhucDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-9329-4287
Budi UtamaShared Equipment Authority, Rice University, Houston, Texas, USA.ORCID 0000-0002-6247-4426
Sarah E BluttDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-4062-709X
Sasirekha RamaniDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-5631-8534
Mary K EstesDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-4813-4249

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
X-ray Crystallographic Studies on CalicivirusesP01AI057788 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI PRASAD, BIDADI VENKATARAM · 2004 to 2024
$34.4M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Novel Platforms for Human Intestinal Enteroids: Matrix, Mechanics, and TopographyU19AI116497 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI ESTES, MARY KOLB · 2015 to 2025
$13.2M
Texas Developmental Center for AIDS ResearchP30AI161943 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 2021 to 2025
$8.3M
CyTOF XT with Hyperion XTi platformS10OD036336 · OD · BAYLOR COLLEGE OF MEDICINE · PI BEETON, CHRISTINE · 2024 to 2024
$829k
NCI NIH HHS P30 CA125123NIAID NIH HHS P01 AI057788NIAID NIH HHS P30 AI161943NIAID NIH HHS U19 AI116497NIDDK NIH HHS P30 DK056338NIH HHS P30AI161943NIH HHS S10 OD036336U.S. Public Health Service AI116497U.S. Public Health Service AI116497, AI057788
6 · The paper itself

Abstract

Human norovirus (HuNoV) causes acute gastroenteritis in immunocompetent hosts and chronic infection in immunocompromised individuals. Many recent studies of replication and innate immune responses following HuNoV infection have utilized epithelium-only human intestinal enteroids (HIEs), which lack immune cells. Here, we utilized an

Indexed as

Caliciviridae InfectionsMacrophagesNorovirusOrganoidsPhagocytosisCoculture TechniquesCytokinesHumansVirus ReplicationCytokineshuman norovirusinnate immunityintestinal enteroidsmacrophagesphagocytosis

Identifiers

PMID40631898
PMCPMC12345152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.