Evidence map›Paper›PMID 40631867›Full record

ArticlemBio2025

Deciphering the viral landscape in gastric cancer: comprehensive characterization and identification of the gastric cancer virome.

Dan Xiang, Shaoying Li, Jiayi Zuo, Chenchen Mao, Yangxuan Lin, Cong Long, Pingping Cai, Weiwei Liu, Xiaorong Lu, Miaofang Xiao and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Comprehensive analysis of the gastric metatranscriptome reveals specific viral signatures associated with gastric cancer.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Dan Xiang *Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.ORCID 0009-0006-3492-203X
Shaoying Li *Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Jiayi Zuo *Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Chenchen Mao *Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Yangxuan LinDepartment of Thoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Cong LongWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Pingping CaiWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Weiwei LiuWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Xiaorong LuWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Miaofang XiaoWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Wangkai XieWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Chenbin ChenWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Dianfeng MeiWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Kezhi LinWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Zheng HanWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Xian ShenDepartment of Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0000-0001-7974-830X
Xiangyang XueWenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.ORCID 0009-0008-3241-5282
Shurong ShenDepartment of Medical Oncology, Wenzhou Central Hospital, Wenzhou, China.ORCID 0009-0003-2146-1260

Funding

National Key Research and Development Program of China 2024YFA0918601National Natural Science Foundation of China 32070151National undergraduate training program for innovation and entrepreneurship 202210343001The Summit Advancement Disciplines of Zhejiang Province (Wenzhou Medical University - Pharmaceutics)wenzhou major Science and Technology Innovation ZY2022015Wenzhou Municipal Science and Technology Bureau Y2020215Zhejiang Provincial Key R&D Program 2020C03029Zhejiang Special Support Program for High-level Talents 2021R52024
6 · The paper itself

Abstract

Infectious diseases caused by pathogenic microorganisms and tumors arising from uncontrolled cell proliferation can be intricately linked through the lens of viromics. This study aimed to delineate the landscape of viral infections in gastric cancer, focusing on the relationship between pathogenic microorganisms and tumorigenesis. By conducting transcriptomic sequencing of gastric cancer tissues, we identified gastric cancer-associated viruses from raw transcriptomic data. This methodology was validated using public databases and experimental evidence, ensuring the authenticity of viral detection. Single-cell data further identified specific cells harboring these viruses and elucidated the correlation between viral gene expression and the genesis and progression of gastric cancer. Common tumor viruses, such as human endogenous retrovirus (HERV), Epstein-Barr virus (EBV), and human cytomegalovirus (HCMV), along with unique DNA viruses and bacteriophages, were detected in gastric cancer. Additionally, these viruses have been detected in both tumor and immune cells, indicating a close association between viral gene expression and the development of gastric cancer. This study advances the technique of screening viruses from transcriptomes, charting the distribution of viruses within tumors, clarifying the interplay between viruses and cancer, and identifying previously unknown viruses related to the occurrence and progression of cancer. IMPORTANCE: In our study, we have carefully examined the viral landscape in gastric cancer, supported by a series of thorough experiments that verify its reliability. Our approach has not only confirmed the presence of viruses known to be associated with cancer development but also identified a range of additional viral entities, including human cytomegalovirus (HCMV) and various herpesviruses, along with numerous bacteriophages. The high incidence of these viruses within tumor samples suggests they could be considered as potential biomarkers for early cancer detection. This method enhances our understanding of the role viruses play in cancer, which may assist scientists and medical professionals in identifying viral presence in cancers and could offer new angles for cancer prevention and the development of related measures. By identifying specific viruses linked to different cancers, we aim to improve patient outcomes.

Indexed as

Stomach NeoplasmsViromeCytomegalovirusEndogenous RetrovirusesGene Expression ProfilingHerpesvirus 4, HumanHumansgastric cancerHERV-Ktumor microenvironmentviral biomarkersvirology map

Identifiers

PMID40631867
PMCPMC12345221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.