Genome Mining Reveals a Novel Nephthenol-Producing Diterpene Synthase from the Sandfly Lutzomyia Longipalpis.

Charles Ducker, Catherine McKeown, Igor F P Da Silva, Isis Torres Souza, John A Pickett, Antônio E G Santana, Neil J Oldham

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Charles DuckerSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Catherine McKeownSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Igor F P Da SilvaSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Isis Torres SouzaInstitute of Chemistry and Biotechnology, Federal University of Alagoas, A. C. Simões Campus, Maceió, AL, 57072-970, Brazil.

John A PickettSchool of Chemistry, Cardiff University, Cardiff, CF10 3AT, UK.ORCID https://orcid.org/0000-0002-8386-3770

Antônio E G SantanaInstitute of Chemistry and Biotechnology, Federal University of Alagoas, A. C. Simões Campus, Maceió, AL, 57072-970, Brazil.

Neil J OldhamSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.ORCID https://orcid.org/0000-0001-8024-4563

Funding

Biotechnology and Biological Sciences Research Council BB/V003933/1

6 · The paper itself

Abstract

Populations of the sandfly, Lutzomyia longipalpis, use the diterpene sobralene as a sex/aggregation pheromone, which is likely produced in the insect through the activity of a recently discovered noncanonical terpene synthase (TPS). This study shows that the genome of this insect also contains another noncanonical TPS able to produce principally (S)-(+)-nephthenol (isoserratol) from geranylgeranyl diphosphate. This diterpene alcohol does not appear to be produced by the sandfly, nor is the corresponding TPS gene transcribed, hence these findings suggest that insects may be a promising source of TPSs for apparently cryptic terpenoid products.

Indexed as

Alkyl and Aryl TransferasesDiterpenesGenome, InsectPsychodidaeAnimalsAlkyl and Aryl TransferasesDiterpenesterpene synthasebiosynthesescryptic natural productsnephthenolssand fliesterpene synthases

Identifiers

PMID40631864

DOI10.1002/cbic.202500292

PMCPMC12376265

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.