Evidence map›Paper›PMID 40631744›Full record

ArticleMicrobiology spectrum2025

Epstein-Barr virus (EBV) infection of endothelial cells via endocytosis is associated with a poor prognosis in nasopharyngeal carcinoma.

Xu-Lin Chen, Zhong-Heng Huang, Xiu-Han Huang, Xi Yao, Ke-Ling Pang, Xin-Lu He, Cui-Juan Luo, Zheng-Bo Wei, Ying Xie

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xu-Lin Chen *Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi, China.ORCID 0009-0005-9101-5324
Zhong-Heng Huang *Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi, China.
Xiu-Han HuangKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi, China.
Xi YaoKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi, China.
Ke-Ling PangKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi, China.
Xin-Lu HeKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi, China.
Cui-Juan LuoKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi, China.
Zheng-Bo WeiKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi, China.ORCID 0000-0001-7858-4796
Ying XieKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi, China.ORCID 0000-0002-8856-4243

Funding

National Natural Science Foundation of China No.82160386Natural Science Foundation of Guangxi Zhuang Autonomous Region 2023GXNSFAA026189Natural Science Foundation of Guangxi Zhuang Autonomous Region 2024GXNSFDA010032Scientific Research and Technology Development Program of Guangxi Zhuang Autonomous Region (Guangxi Science and Technology Planning Project) AD25069077
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) infection is strongly associated with several malignancies, including nasopharyngeal carcinoma (NPC), Burkitt lymphoma, and certain gastric cancers, though its potential to infect endothelial cells (ECs) and the consequent pathological implications remain poorly understood. This study demonstrates through analysis of 99 NPC clinical samples (primary tumors) that Epstein-Barr virus-encoded small RNAs (EBERs) positivity in ECs significantly correlates with N stage (lymphatic metastasis,

Indexed as

EndocytosisEndothelial CellsEpstein-Barr Virus InfectionsHerpesvirus 4, HumanNasopharyngeal CarcinomaNasopharyngeal NeoplasmsAdultAgedB-LymphocytesCell Line, TumorFemaleHumansMaleMiddle AgedPrognosisEBVendothelial cellsnasopharyngeal carcinomaprognosis

Identifiers

PMID40631744
PMCPMC12323331

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.