Evidence map›Paper›PMID 40631637›Full record

ArticleJournal of surgical oncology2025

Bilateral Risk-Reducing Mastectomy With Immediate Breast Reconstruction Lowers Concerns of Breast Cancer in Women With a High-Risk Genetic Predisposition for Breast Cancer Compared With a Radiological Imaging Surveillance Group.

Cecilie Balslev Willert, Pernille Bidstrup, Lene Mellemkjær, Julie Kalstrup, Anne-Marie Axø Gerdes, Niels Kroman, Lene Birk-Sørensen, Rikke Bredgaard, Signe Muus Steffensen, Lena Felicia Carstensen and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cecilie Balslev WillertDepartment of Plastic Surgery, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.ORCID https://orcid.org/0000-0001-5255-8346
Pernille BidstrupPsychological Aspects of Cancer, Danish Cancer Institute, Copenhagen, Denmark.
Lene MellemkjærDiet, Cancer and Health, Danish Cancer Institute, Copenhagen, Denmark.
Julie KalstrupDepartment of Plastic Surgery, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.
Anne-Marie Axø GerdesDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Niels KromanDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Lene Birk-SørensenDepartment of Plastic and Breast Surgery, Aalborg University Hospital, Aalborg, Denmark.
Rikke BredgaardDepartment of Plastic Surgery, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.
Signe Muus SteffensenDepartment of Plastic Surgery, University Hospital of Southern Denmark, Odense, Denmark.
Lena Felicia CarstensenDepartment of Surgery, Hospital of Southwest Jutland, Esbjerg, Denmark.
Lisbet Rosenkrantz HölmichDepartment of Plastic Surgery, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.

Funding

The study was funded by Helsefonden (ID 19-B-0281), the Danish Cancer Society Psychosocial Fund (ID R224-A13361), and Holm's Memorial Grant.
6 · The paper itself

Abstract

BACKGROUND AND

objectivesWomen with a high-risk genetic predisposition for breast cancer are faced with the choice between bilateral risk-reducing mastectomy, often accompanied by immediate breast reconstruction, or radiological imaging surveillance. This study examined changes in mental well-being and health-related quality of life following surgery and compared outcomes with women adhering to surveillance. Additionally, surgical complications and regrets were assessed.

methodsPatients were recruited from multiple clinical departments across Denmark and stratified into surgery or surveillance groups. Patient-reported outcomes were measured using validated questionnaires, including the BREAST-Q, at baseline and 3, 12, and 24 months post-surgery or post-baseline.

resultsA total of 35 and 37 patients were included in the surgery and surveillance groups, respectively. Surgery significantly reduced concerns about developing breast cancer but also led to lower physical well-being. Significant between-group differences were found at all post-baseline time points for these outcomes. Surgically and conservatively treated complications occurred in 14% and 23% of patients, respectively. No patients regretted the surgery.

conclusionsRisk-reducing mastectomy with immediate reconstruction effectively reduces breast cancer concerns in high-risk women in the short and long term but at the cost of reduced physical well-being and potential complications. These findings are essential for aligning preoperative expectations.

Indexed as

Breast NeoplasmsGenetic Predisposition to DiseaseMammaplastyMastectomyProphylactic MastectomyAdultAgedDenmarkFemaleFollow-Up StudiesHumansMiddle AgedPatient Reported Outcome MeasuresQuality of LifeSurveys and Questionnairesbilateral risk‐reducing mastectomygenetic predisposition for breast cancerhealth‐related quality of lifeimmediate breast reconstructionmental well‐beingpatient‐reported outcome measurements

Identifiers

PMID40631637
PMCPMC12455535

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.