Evidence map›Paper›PMID 40631515›Full record

ArticleOncoimmunology2025

An SNP-dependent cancer-testis antigenic epitope serves as a promising immunotherapeutic target for cancer.

Kenji Murata, Tomoyuki Minowa, Tomohide Tsukahara, Taku Yoshida, Akiko Minami, Munehide Nakatsugawa, Yuka Mizue, Aiko Murai, Serina Tokita, Kenta Sasaki and 5 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Kenji MurataDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.ORCID 0000-0002-2613-5144
Tomoyuki MinowaDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Tomohide TsukaharaDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Taku YoshidaDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Akiko MinamiDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Munehide NakatsugawaDepartment of Pathology, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo, Japan.
Yuka MizueDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Aiko MuraiDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Serina TokitaDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Kenta SasakiDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Hisashi UharaDepartment of Dermatology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Terufumi KuboDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Takayuki KanasekiDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Toshihiko TorigoeDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Yoshihiko HirohashiDepartment of Pathology, Sapporo Medical University, Sapporo, Hokkaido, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cells recognize peptides presented by human leukocyte antigen molecules on the cell surface, enabling the immune surveillance of pathological conditions such as cancer. Cancer-testis (CT) antigens are promising targets for cancer immunotherapy because of their restricted expression in normal tissues. In this study, we performed antigen screening of T cell receptors isolated from tumor-infiltrating lymphocytes (TILs) in acral melanoma, using cDNA expression cloning and identified a novel CT antigenic epitope encoded by

Indexed as

Antigens, NeoplasmEpitopesEpitopes, T-LymphocyteMelanomaNeoplasm ProteinsPolymorphism, Single NucleotideHumansImmunotherapyLymphocytes, Tumor-InfiltratingMaleReceptors, Antigen, T-CellTestisAntigens, NeoplasmEpitopesEpitopes, T-LymphocyteNeoplasm ProteinsReceptors, Antigen, T-CellAntigenic epitopecancer-testis antigencDNA expression cloningsingle nucleotide polymorphismtumor-infiltrating lymphocytes

Identifiers

PMID40631515
PMCPMC12243901

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.