Evidence map›Paper›PMID 40631509›Full record

ArticleThe Laryngoscope2025

Relationship Between Lesion Size, Voice Quality, and Quality of Life in Children With Vocal Nodules.

Rita R Patel, Shaheen N Awan, Maggie Stall, Benjamin Seiwert, Nassim Ahmadi, Hagar Feinstein, Diane Chen, Lauren Sowa, Joseph E Dohar, Katherine Verdolini Abbott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rita R PatelDepartment of Otolaryngology-Head and Neck Surgery, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0002-5354-5210
Shaheen N AwanSchool of Communication Sciences and Disorders and Communication Technologies Research Center, University of Central Florida, Orlando, Florida, USA.ORCID 0000-0003-3331-4156
Maggie StallDepartment of Speech, Language and Hearing Sciences, Indiana University, Bloomington, Indiana, USA.
Benjamin SeiwertDepartment of Speech, Language and Hearing Sciences, Indiana University, Bloomington, Indiana, USA.
Nassim AhmadiDepartment of Communication Sciences and Disorders, University of Delaware, Newark, Delaware, USA.
Hagar FeinsteinPrivate Practice, Ramat Yohana, Israel.
Diane ChenDepartment of Otolaryngology-Head and Neck Surgery, Indiana University, Indianapolis, Indiana, USA.
Lauren SowaDepartment of Otolaryngology-Head and Neck Surgery, Indiana University, Indianapolis, Indiana, USA.
Joseph E DoharDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Katherine Verdolini AbbottDepartment of Communication Sciences and Disorders, University of Delaware, Newark, Delaware, USA.

Funding

Cognitive and Biological Mechanisms in Pediatric Voice TherapyR01DC017923 · NIDCD · UNIVERSITY OF DELAWARE · PI VERDOLINI, KATHERINE · 2019 to 2023
$3.1M
NIDCD NIH HHS R01 DC017923
6 · The paper itself

Abstract

objectiveTo examine the relationship between lesion size, auditory-perceptual ratings, patient-related quality of life measure, and acoustic voice measures in children with vocal nodules.

methodsThirteen children (5-10 years) with vocal nodules were recruited in this cross-sectional cohort study. Auditory-perceptual ratings of overall voice severity were performed using a Visual Analog Scale. Acoustic measures of cepstral peak prominence (CPP), low/high ratio, and the Cepstral Spectral Index of Dysphonia (CSID) were computed on vowels /a:/, /i:/, and an all-voiced sentence. The Nuss scale was used to rate lesion size from high-speed videoendoscopy (HSV). Patient Voice-Related Quality of Life (PVRQOL) was obtained from both the child and the parent. Correlations were computed for HSV ratings vs. auditory ratings, PVRQOL ratings, and acoustic measures as well as for interrelationships among all variables.

resultsLesion size on HSV correlated moderately with overall severity of auditory-perceptual voice rating and with acoustic measures CPP and CSID, but not with PVRQOL. Significant, strong correlations were observed between auditory ratings and CPP, L/H ratio, and CSID in vowels and sentences. Several moderate strength correlations were observed between PVRQOL subscales (parental and child physical function; child social emotional well-being) and acoustic measures.

conclusionsSince nodules influence both vocal fold structure and vocal function, multiple parameters (lesion size, auditory-perceptual ratings, measures of physical function and social-emotional impact, and acoustic measurements) are needed to fully characterize the potential effect(s) on the voice. These findings could be used to improve clinical assessment and outcome measurements in children with vocal fold nodules. LEVEL OF EVIDENCE: 3:

Indexed as

DysphoniaLaryngeal DiseasesQuality of LifeVocal CordsVoice QualityChildChild, PreschoolCross-Sectional StudiesFemaleHumansMaleSeverity of Illness Indexacoustic analysisauditory‐perceptual voice analysislesion sizepediatric vocal fold nodules

Identifiers

PMID40631509
PMCPMC12307008

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.