Evidence map›Paper›PMID 40631447›Full record

Observational studyDiabetes, obesity & metabolism2025

Ethnicity and socioeconomic status do not influence glycaemic outcomes of a tubeless hybrid closed-loop system (Omnipod® 5) in adults with type 1 diabetes.

Ananthi Anandhakrishnan, Siobhan Pender, Thomas Johnston, Rebecca Hyslop, Yuk-Fun Liu, Dulmini Kariyawasam, Anna Brackenridge, Janaka Karalliedde, Sufyan Hussain

Abstract readObservational StudyMulticenter Study
In one paragraph

Observational study in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ananthi AnandhakrishnanDepartment of Diabetes and Endocrinology, Guy's Hospital, Guys and St Thomas' NHS Trust, London, UK.ORCID 0009-0002-9547-3355
Siobhan PenderDepartment of Diabetes and Endocrinology, Guy's Hospital, Guys and St Thomas' NHS Trust, London, UK.
Thomas JohnstonDepartment of Diabetes and Endocrinology, Guy's Hospital, Guys and St Thomas' NHS Trust, London, UK.
Rebecca HyslopDepartment of Diabetes and Endocrinology, Guy's Hospital, Guys and St Thomas' NHS Trust, London, UK.
Yuk-Fun LiuDepartment of Diabetes and Endocrinology, Guy's Hospital, Guys and St Thomas' NHS Trust, London, UK.ORCID 0000-0002-8518-8756
Dulmini KariyawasamDepartment of Diabetes and Endocrinology, Guy's Hospital, Guys and St Thomas' NHS Trust, London, UK.ORCID 0000-0001-6896-8251
Anna BrackenridgeDepartment of Diabetes and Endocrinology, Guy's Hospital, Guys and St Thomas' NHS Trust, London, UK.
Janaka KarallieddeDepartment of Diabetes and Endocrinology, Guy's Hospital, Guys and St Thomas' NHS Trust, London, UK.ORCID 0000-0002-2617-8320
Sufyan HussainDepartment of Diabetes and Endocrinology, Guy's Hospital, Guys and St Thomas' NHS Trust, London, UK.ORCID 0000-0001-6611-8245

Funding

Abbott Diabetes CareInsulet CorporationMedical Research Council MR/W030004/1
6 · The paper itself

Abstract

aimsWe aimed to evaluate real-world glycaemic outcomes of a tubeless hybrid closed-loop (HCL) insulin delivery system in type 1 diabetes (T1D), exploring the influence of ethnicity and socioeconomic status from a publicly funded system with universal access. MATERIALS AND

methodsThis was a retrospective observational study in adults with T1D initiating HCL (Omnipod® 5) at a large publicly funded multi-site diabetes service. Baseline glycaemic metrics were compared with 12-week post-initiation data. Clinical data and social determinants of health, such as ethnicity and socioeconomic deprivation indices, were analysed for subgroup differences.

resultsOne hundred and sixty adults with T1D were included (26.9% non-White; 48.8% in the two most deprived IMD quintiles). Mean time in range (%TIR; 3.9-10 mmol/L) improved from 52.7 ± 16% to 67.9 ± 12.7% (p < 0.001). Improvements were consistent across ethnic groups (mean % TIR +14.8% [95% CI: (12.6%, 17.3%)] and + 16.1% [95% CI: 12.4%, 19.7%] in White and non-White individuals, respectively, p = 0.488) and socioeconomic strata (mean % TIR + 15.9% [95% CI: 13.3%, 18.6%] and + 14.2% [95% CI: 11.2%, 17.1%] in those from lower and higher socioeconomic groups, respectively, p = 0.290). Those with poorer baseline glycaemia experienced greater improvements.

conclusionsEarly real-world use of a tubeless HCL system demonstrated significant and equal glycaemic improvements in diverse ethnic and socioeconomic groups. Promoting universal access to HCL technologies in T1D is therefore essential to ensure existing disparities in glycaemic outcomes are minimised.

Indexed as

Diabetes Mellitus, Type 1Hypoglycemic AgentsInsulinInsulin Infusion SystemsSocial ClassAdultBlood GlucoseBlood Glucose Self-MonitoringEthnicityFemaleGlycated HemoglobinGlycemic ControlHumansMaleMiddle AgedRetrospective StudiesBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinethnic diversityhybrid closed loop systempublicly funded healthcare systemreal‐world evidencesocioeconomic deprivationtype 1 diabetes

Identifiers

PMID40631447
PMCPMC12326946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.