Evidence map›Paper›PMID 40631437›Full record

ArticleCurrent eye research2025

Characterizing Retinal Mitochondrial Function and Its Relations to Intraretinal Thicknesses in Healthy Adults.

Colin K Kim, Giovana R Gameiro, Ava-Gaye Simms, Byron L Lam, Collin A Rich, Jianhua Wang, Hong Jiang

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Article in Current eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Colin K KimUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Giovana R GameiroBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Ava-Gaye SimmsBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Byron L LamBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Collin A RichOcuSciences, Inc, Ann Arbor, MI, USA.
Jianhua WangBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Hong JiangBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Novel Biomarkers of Small Vessel Contributions to Vascular Cognitive Impairment and Dementia (VCID)R01NS111115 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A, WANG, JIANHUA · 2019 to 2023
$3.7M
NEI NIH HHS P30 EY014801NINDS NIH HHS R01 NS111115
6 · The paper itself

Abstract

purposeTo characterize retinal mitochondrial function and its relationship with intraretinal thicknesses in healthy adults.

methodsRetinal flavoprotein fluorescence (FPF), a marker of mitochondrial function, was measured using the OcuMet Beacon (OcuSciences, Inc., Ann Arbor, MI), and a stress index (SI) was computed using Enhanced Retinal Metabolic Analysis software 2.0 (RMA). After lens compensation, mean FPF in the macula and optic nerve head (ONH) was obtained. The macular SI summarizes FPF heterogeneity, while the ONH SI reflects the extent to which ONH FPF exceeds a normative threshold. Intraretinal layer thicknesses and total retinal thickness (TRT) were measured

resultsMacular and ONH FPF were inversely correlated with TRT (

conclusionThis study is the first to examine the relationship between retinal mitochondrial function and intraretinal layer thicknesses in healthy adults. Findings suggest that age mediates the observed associations.

Indexed as

MitochondriaRetinaAdultAgedAged, 80 and overCross-Sectional StudiesFemaleHealthy VolunteersHumansMaleMiddle AgedNerve FibersOptic DiskRetinal Ganglion CellsTomography, Optical CoherenceYoung Adulthealthy adultsintraretinal thicknessesoptical coherence tomographyRetinal mitochondrial function

Identifiers

PMID40631437
PMCPMC12313233

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.