Evidence map›Paper›PMID 40631432›Full record

ArticleDrug delivery2025

Biomimetic cancer cell membrane-enriched vitamin E-stapled gemcitabine-loaded TPGS micelles for pancreatic cancer therapy.

Miguel Pereira-Silva, Luis Diaz-Gomez, Bárbara Blanco-Fernandez, Ana Cláudia Paiva-Santos, Francisco Veiga, Angel Concheiro, Carmen Alvarez-Lorenzo

Abstract read
In one paragraph

Article in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Significance of Vitamins A and E in Cancer Progression and Prevention.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miguel Pereira-SilvaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Luis Diaz-GomezDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, I + D Farma, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Bárbara Blanco-FernandezDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, I + D Farma, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Ana Cláudia Paiva-SantosDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Francisco VeigaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Angel ConcheiroDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, I + D Farma, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Carmen Alvarez-LorenzoDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, I + D Farma, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer (PC) is currently a leading cause of death worldwide and its incidence is expected to increase in the following years. Chemotherapy with gemcitabine (GEM) is precluded by extensive enzymatic inactivation and clearance, and the nonspecific tissue distribution contributes to unwanted systemic toxicity and tumor resistance. In this work, GEM was encapsulated in d-ɑ-tocopheryl polyethylene glycol succinate (TPGS) micelles by 'stapling' GEM at 4-NH

Indexed as

Antimetabolites, AntineoplasticCell MembraneDeoxycytidinePancreatic NeoplasmsVitamin EBiomimeticsCell Line, TumorCell SurvivalDrug CarriersDrug LiberationGemcitabineHumansMicellesParticle SizePolyethylene GlycolsProdrugsAntimetabolites, AntineoplasticDeoxycytidineDrug CarriersGemcitabineMicellesPolyethylene GlycolsProdrugstocophersolanVitamin Ebiomimeticcell membrane coatingchemotherapygemcitabinepancreatic cancerPolymeric micellevitamin E-based nanosystem

Identifiers

PMID40631432
PMCPMC12243015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.