ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2025
Remoscope: a label-free imaging cytometer for malaria diagnostics.
Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Unstained Blood Smear Analysis: A Review of Rule-Based, Machine Learning, and Deep Learning Techniques.Journal of biophotonics · 2025Review
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18 authors.
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Abstract
backgroundMalaria diagnostic testing remains a burden on healthcare systems. Here we present Remoscope, a portable imaging cytometer that scans fresh, unstained whole blood using a custom neural network running on low-cost hardware. Remoscope performs label-free, quantitative, stage-specific detection of Plasmodium falciparum (Pf) by screening up to 2 million red blood cells (RBCs) in 1-12 min, without sample fixation, staining or slide scanning. Low-cost disposable cartridges are used to confine flowing blood to an ultrathin sheet for imaging.
methodsPerformance was benchmarked in vitro by titration of cultured Pf (17.1-710 000 parasites/µl) into whole blood. A study of Remoscope's diagnostic accuracy was evaluated in a cohort of 500 individuals in eastern Uganda, comprising 601 unique clinic visits. Parallel measurements of parasitaemia were performed using Remoscope, quantitative polymerase chain reaction (qPCR) and thick blood smears.
resultsClinically, Remoscope's 10× diluted blood assay had a limit of detection with respect to qPCR of 95.1 parasites/µl, sensitivity of 83%, specificity of 96%, positive predictive value of 91% and negative predictive value of 93%.
conclusionsRemoscope's speed, accuracy, cost and ease of use address key challenges in malaria diagnosis worldwide. In this pilot study, the diagnostic accuracy approaches that of expert thick smears performed in duplication.
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