Evidence map›Paper›PMID 40631384›Full record

ArticleActa physiologica (Oxford, England)2025

Loss of Na

María S Espejo, Alejandro Orlowski, Trine M Sørensen, Vladimir V Matchkov, Ernesto A Aiello, Ebbe Boedtkjer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Loss of NaActa physiologica (Oxford, England) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

María S EspejoDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-6618-7697
Alejandro OrlowskiCentro de Investigaciones Cardiovasculares "Dr. Horacio Cingolani", Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Argentina.
Trine M SørensenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Vladimir V MatchkovDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-3303-1095
Ernesto A AielloCentro de Investigaciones Cardiovasculares "Dr. Horacio Cingolani", Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Argentina.ORCID https://orcid.org/0000-0002-8914-5067
Ebbe BoedtkjerDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-5078-9279

Funding

Aarhus Universitets ForskningsfondCoimbra Exchange NetworkDanish Cardiovascular Academy NNF20SA0067242Novo Nordisk Fonden NNF21OC0071822Universidad Nacional de La Plata
6 · The paper itself

Abstract

aimMetabolic disturbances challenge pH homeostasis in cardiomyocytes. The electroneutral Na

methodsBased on mice with global loss of NBCn1, we measure intracellular pH in atria and ventricles of the heart (fluorescence microscopy), membrane potential responses (patch clamping), electro- and echocardiographic variables, blood pressure (telemetry), and cardiac dimensions (in vivo and postmortem analyses).

resultsWe find that protein and mRNA expression of NBCn1 are more prominent in atrial than in ventricular cardiomyocytes. Disruption of NBCn1 expression lowers Na

conclusionNBCn1 is a main mechanism of Na

Indexed as

CardiomegalyHeart AtriaHypertensionSodium-Bicarbonate SymportersAnimalsBlood PressureHydrogen-Ion ConcentrationMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacSlc4a7 protein, mouseSodium-Bicarbonate Symporterscardiac functionechocardiographyhypertensionhypertrophy

Identifiers

PMID40631384
PMCPMC12238920

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.