Evidence map›Paper›PMID 40631323›Full record

ArticlebioRxiv : the preprint server for biology2025

Establishment, conservation, and innovation of dorsal determination mechanisms during the evolution of vertebrate paired appendages.

M Brent Hawkins, Sofía Zdral, Silvia Naranjo, Miguel Juliá, Manuel Sánchez-Martín, Jacob M Daane, Nicolas Cumplido, David Jandzik, Daniel M Medeiros, Sarah K McMenamin and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

M Brent HawkinsBoston Children's Hospital Department of Orthopedic Research, Boston, MA (USA).ORCID 0000-0002-5164-2893
Sofía ZdralInstituto de Biotecnología y Biomedicina de Cantabria CSIC-SODERCAN-Universidad de Cantabria (Spain).ORCID 0000-0001-6928-3529
Silvia NaranjoCentro Andaluz de Biología de Desarrollo CSIC-Universidad Pablo de Olavide (Spain).ORCID 0000-0002-4529-3332
Miguel JuliáInstituto de Biotecnología y Biomedicina de Cantabria CSIC-SODERCAN-Universidad de Cantabria (Spain).
Manuel Sánchez-MartínInstitute of Biomedical Research of Salamanca (IBSAL) Universidad de Salamanca (Spain).
Jacob M DaaneDepartment of Biology and Biochemistry, University of Houston, TX (USA).ORCID 0000-0003-3631-4514
Nicolas CumplidoBiology Department, Boston College, Chestnut Hill, Massachusetts (USA).ORCID 0000-0001-8581-4588
David JandzikDepartment of Zoology, Comenius University in Bratislava (Slovakia).ORCID 0000-0002-4239-0014
Daniel M MedeirosDepartment of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO (USA).ORCID 0000-0002-8182-6028
Sarah K McMenaminBiology Department, Boston College, Chestnut Hill, Massachusetts (USA).ORCID 0000-0002-1154-5810
Matthew P HarrisBoston Children's Hospital Department of Orthopedic Research, Boston, MA (USA).ORCID 0000-0002-7201-4693
Juan J TenaCentro Andaluz de Biología de Desarrollo CSIC-Universidad Pablo de Olavide (Spain).ORCID 0000-0001-8165-7984
Marian A RosInstituto de Biotecnología y Biomedicina de Cantabria CSIC-SODERCAN-Universidad de Cantabria (Spain).ORCID 0000-0002-1224-7671

Funding

A novel role for Wasl signaling in the regulation of skeletal patterningR01HD112906 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Matthew P Harris · 2023 to 2026
$2.1M
Illuminating the mechanisms that generate pattern and shape during growth and regeneration of the zebrafish finR35GM146467 · NIGMS · BOSTON COLLEGE · PI Sarah Kelly McMenamin · 2022 to 2026
$1.9M
Phylogenomic mechanisms of trait evolution and resilience to diseaseR35GM150590 · NIGMS · UNIVERSITY OF HOUSTON · PI Jacob Michael Daane · 2023 to 2026
$1.6M
NICHD NIH HHS R01 HD112906NIGMS NIH HHS R35 GM146467NIGMS NIH HHS R35 GM150590
6 · The paper itself

Abstract

Limb function requires polarized anatomy across the dorsal-ventral (DV) axis, but it is unclear when the capacity for DV differentiation of paired appendages arose in evolution. Here we define ancestral DV patterning programs in the fins of fishes. We show that the orthologue of the limb dorsal determinant, Lmx1b, is required to establish dorsality in zebrafish pectoral fins and is regulated by a conserved

Indexed as

developmentdorsal-ventral patterningenhancerEvolutionfin-to-limb transitiongeneticslampreyloachmouseskeletonzebrafish

Identifiers

PMID40631323
PMCPMC12236613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.