ArticlebioRxiv : the preprint server for biology2025
Phase-Specific Antibiotic Resistance Mechanisms in an
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
The majority of antibiotics developed to date target the fast-growing phase of bacteria, which typically occurs during active infection and resembles the exponential growth phase of laboratory-grown cultures. However, many pathogenic bacteria in the human body occupy environments where nutrients are limited and persist in a low-metabolic state, mirroring the stationary phase observed in laboratory-grown cultures. Bacteria in this latter phase are generally more resistant to antibiotics and are often responsible for recurrent infections. A comprehensive understanding of metabolic processes in both the exponential and stationary phases of bacterial growth could facilitate the development of phase-specific antibiotics. In this study, we adopted an untargeted proteomics approach to establish similarities and differences in the exponential and stationary phase proteome landscapes in BLR (DE3) cells, an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.