ArticlebioRxiv : the preprint server for biology2025
Micron-scale protein transport along microtubules by kinesin-driven shepherding.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
Abstract
Microtubule-based long-distance transport in eukaryotic cells typically involves the binding of cargo to motors such as highly processive kinesins for unidirectional transport. An open question is whether long-distance transport can occur by mechanisms that do not require specific motor-cargo interactions and high processivity. In addition to conventional cargo such as vesicles, kinesin also shuttles non-motor microtubule-associated proteins (MAPs) to microtubule ends. Computational modeling of a system of a motor and a MAP that do not bind directly with one another unexpectedly revealed the redistribution of the MAP to microtubule plus ends, suggesting an unconventional mode of protein transport. We recapitulated this phenomenon experimentally in a minimal
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