Evidence map›Paper›PMID 40631288›Full record

ArticlebioRxiv : the preprint server for biology2025

An Epigenomic Roadmap Primes Non-Growing Oocytes for Maturation and Early Embryogenesis.

Mengwen Hu, Yasuhisa Munakata, Yu-Han Yeh, Han Wang, Neil Hunter, Richard M Schultz, Satoshi H Namekawa

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengwen HuDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-7480-6432
Yasuhisa MunakataDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-5134-0828
Yu-Han YehDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-2369-4415
Han WangDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.
Neil HunterDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-1498-2327
Richard M SchultzDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.
Satoshi H NamekawaDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-1052-943X

Funding

Epigenetic gene regulations in the germlineR35GM141085 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satoshi Namekawa · 2021 to 2026
$4.4M
Ovarian reserve formation and maintenanceR21HD110146 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAMEKAWA, SATOSHI, SCHULTZ, RICHARD MORRIS · 2023 to 2024
$440k
NICHD NIH HHS R21 HD110146NIGMS NIH HHS R35 GM141085
6 · The paper itself

Abstract

Female reproductive lifespan is defined by long-lived, non-growing oocytes (NGOs) that comprise the ovarian reserve. NGOs are assumed to acquire the epigenetic marks that will define the early embryo only after they exit the ovarian reserve and become activated for growth. Contrary to this dogma, we show that mouse NGOs possess abundant histone modifications that both underlie maintenance of the ovarian reserve and prime the epigenome of growing oocytes for early embryogenesis. As NGOs are established around birth, Polycomb Repressive Complex 1 (PRC1) mediates abundant H2AK119 ubiquitylation and reprograms the H3K27 acetylation landscape, which is essential to maintain the ovarian reserve. Importantly, the PRC1-driven epigenetic state of NGOs provides a blueprint for subsequent generation of a PRC2-catalyzed H3K27 trimethylation profile in growing oocytes that is characterized by broad domains and DNA methylation-independent imprints that are transmitted to the embryo. Thus, Polycomb complexes play pivotal roles in priming the NGO epigenome for oocyte maturation and early embryogenesis.

Indexed as

EpigeneticsEpigenomicsGermlineImprintingOogenesisOvarian reservePolycomb

Identifiers

PMID40631288
PMCPMC12236492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.