Evidence map›Paper›PMID 40631281›Full record

ArticlebioRxiv : the preprint server for biology2025

Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline.

Sara C Sebag, Tate Neff, Qingwen Qian, Arvand Asghari, Zhuozhi Wang, Zeyuan Zhang, Mark Li, Meihua Hao, Vitor A Lira, Hongli Sun and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sara C SebagDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Tate NeffDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Qingwen QianDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Arvand AsghariDepartment of Neuroscience and Pharmacology, Fraternal Order of Eagles Diabetes Research Center Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Zhuozhi WangDepartment of Oral and Maxillofacial Surgery, University of Iowa College of Dentistry, Iowa City, IA, 52242, USA.
Zeyuan ZhangDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Mark LiDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Meihua HaoDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Vitor A LiraDepartment of Health and Human Physiology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-3162-3804
Hongli SunDepartment of Oral and Maxillofacial Surgery, University of Iowa College of Dentistry, Iowa City, IA, 52242, USA.
Matthew J PotthoffDepartment of Neuroscience and Pharmacology, Fraternal Order of Eagles Diabetes Research Center Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Ling YangDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.ORCID 0000-0002-3105-3063

Funding

University of Iowa Institutional Training Program in Oral Health ResearchT90DE023520 · NIDCR · UNIVERSITY OF IOWA · PI STEVEN M. LEVY · 2013 to 2026
$5.6M
Role of ADH5 in the Regulation of Brown Adipose Tissue Metabolic HomeostasisR01DK126817 · NIDDK · UNIVERSITY OF IOWA · PI YANG, LING · 2022 to 2025
$2.0M
NIDCR NIH HHS T90 DE023520NIDDK NIH HHS R01 DK126817
6 · The paper itself

Abstract

Aging-associated decline in brown adipose tissue (BAT) function and mass contributes to energy and metabolic homeostasis disruption. Alcohol dehydrogenase 5 (ADH5) is a major denitrosylase that prevents cellular nitro-thiol redox imbalance, an essential feature of aging. However, the functional significance of BAT ADH5 in the context of aging is largely unknown. Here, we aimed to investigate the role of BAT ADH5 in protecting against age-related metabolic dysfunction. We show that aging promotes aberrant BAT protein S-nitrosylation modification and downregulates ADH5 in mice. Furthermore, BAT ADH5-deletion accelerates BAT senescence and aging-associated declines in metabolic homeostasis and cognition. Mechanistically, we found that aging inactivates BAT

Indexed as

Adipose tissueAgingMetabolic DysfunctionNitrosative Stress

Identifiers

PMID40631281
PMCPMC12236652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.