Evidence map›Paper›PMID 40631231›Full record

ArticlebioRxiv : the preprint server for biology2025

The accessory protein CvnF8 modulates histidine kinase activity in an Actinobacterial G protein system in

Luis M Cantu Morin, Kilian Dekoninck, Kyung-Yoon Min, Matthew F Traxler

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Luis M Cantu MorinDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Kilian DekoninckDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Kyung-Yoon MinDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Matthew F TraxlerDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.ORCID 0000-0001-8430-595X

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
Connecting specialized metabolism to social cues in actinomycete bacteriaR35GM128849 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Matthew F Traxler · 2018 to 2026
$3.3M
NCI NIH HHS P30 CA082103NIGMS NIH HHS R35 GM128849
6 · The paper itself

Abstract

Conservons are regulatory systems found in bacteria of the phylum Actinomycetota. These regulatory systems are composed of four core proteins: a sensor histidine kinase-like protein (CvnA homolog), an MglA-type roadblock protein (CvnB homolog), a protein containing a domain of unknown function (CvnC homolog), and small Ras-like GTPase (CvnD homolog). Based on their conserved small GTPase components and their phylogenetic distribution, we propose that conservons should be known as Actinobacterial G protein systems (AGPSs). The signal transduction path through AGPSs remains poorly understood, and some AGPSs have additional accessory proteins (CvnE and CvnF homologs) of unknown function. In this work, we show that AGPS accessory proteins are present when the cognate histidine kinase protein (CvnA homolog) lacks an extracytoplasmic sensory domain. It was previously shown that the Cvn8 AGPS of

Identifiers

PMID40631231
PMCPMC12236503

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.