Evidence map›Paper›PMID 40631220›Full record

ArticlebioRxiv : the preprint server for biology2025

Sensitivity of genome-wide tests for mitonuclear genetic incompatibilities.

Shady A Kuster, Molly Schumer, Justin C Havird, Daniel B Sloan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Shady A KusterCell and Molecular Biology, Colorado State University.ORCID 0000-0003-2721-6779
Molly SchumerDepartment of Biology, Stanford University.ORCID 0000-0002-2075-5668
Justin C HavirdDepartment of Integrative Biology, University of Texas at Austin.
Daniel B SloanDepartment of Biology, Colorado State University.

Funding

Predoctoral Training in Quantitative Cell & Molecular BiologyT32GM132057 · NIGMS · COLORADO STATE UNIVERSITY · PI Karen Marie Dobos, Brian Munsky · 2019 to 2026
$2.9M
Causes and Consequences of Mitochondrial MutationsR35GM142836 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI HAVIRD, JUSTIN C · 2021 to 2025
$2.0M
Mechanisms of mitochondrial mutation rate variation across eukaryotesR35GM148134 · NIGMS · COLORADO STATE UNIVERSITY · PI Daniel Benjamin Sloan · 2023 to 2026
$1.7M
NIGMS NIH HHS R35 GM142836NIGMS NIH HHS R35 GM148134NIGMS NIH HHS T32 GM132057
6 · The paper itself

Abstract

Mismatches between interacting mitochondrial and nuclear gene products in hybrids have been proposed to disproportionately contribute to the formation of early species boundaries. Under this model, genetic incompatibilities emerge when mitochondrial haplotypes are placed into a cellular context without their coevolved nuclear-encoded mitochondrial (n-mt) proteins. Although there is strong evidence that mitonuclear coevolution has contributed to reproductive isolation in some cases, it is less clear how far-reaching the effects of mitonuclear incompatibilities are in speciation. Does disrupting co-adapted mitonuclear genotypes have broad, genome-wide effects with numerous n-mt loci contributing to reproductive isolation? We leverage a system with several hybridizing species pairs (

Identifiers

PMID40631220
PMCPMC12236695

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.