Evidence map›Paper›PMID 40631208›Full record

ArticlebioRxiv : the preprint server for biology2025

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in mice.

Xuexi Zhang, Xue Liu, Yujie Qiao, Anas Rabata, Ningshan Liu, Changfu Yao, Tanyalak Parimon, Danica Chen, Peter Chen, Barry Stripp and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Xuexi Zhang
Xue Liu
Yujie Qiao
Anas Rabata
Ningshan Liu
Changfu Yao
Tanyalak Parimon
Danica Chen
Peter Chen
Barry Stripp
Stephen J Gardell
Paul W Noble
Jiurong Liang

Funding

ZIP8-dependent Zinc Metabolic Regulation in Alveolar Progenitor Cell Aging and FibrosisR01AG078655 · NIA · CEDARS-SINAI MEDICAL CENTER · PI Carol Jiurong Liang, Paul Wesley Noble · 2022 to 2026
$2.7M
PRC2 independent role of Ezh2 in regulation of basal cell dynamics post-influenza virus infectionR01HL174973 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Changfu Yao · 2024 to 2026
$1.7M
NHLBI NIH HHS R01 HL174973NIA NIH HHS R01 AG078655
6 · The paper itself

Abstract

Alveolar type II (AT2) progenitor cell exhaustion and impaired regenerative capacity are key pathogenic hallmarks in idiopathic pulmonary fibrosis (IPF). Nicotinamide adenine dinucleotide (NAD

Identifiers

PMID40631208
PMCPMC12236712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.