Evidence map›Paper›PMID 40631133›Full record

ArticlebioRxiv : the preprint server for biology2025

PHASE SEPARATION TUNES THE STABILITY AND DYNAMICS OF G-QUADRUPLEX AND I-MOTIF DNA IN THE NUCLEI OF LIVING CELLS.

Brahmmi Patel, Cailin Hoang, Hyejin Yoo, Caitlin Davis

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brahmmi PatelDepartment of Chemistry, Yale University, New Haven, Connecticut, 06511-6712, United States.
Cailin HoangPresent Address: NYU Langone Health, New York, New York, 10016, United States.
Hyejin YooPresent Address: Physical Sciences Inc., Andover, Massachusetts, 01810, United States.
Caitlin DavisDepartment of Chemistry, Yale University, New Haven, Connecticut, 06511-6712, United States.

Funding

Predoc Training at the Interface Chemistry and BiologyT32GM067543 · NIGMS · YALE UNIVERSITY · PI CRAWFORD, JASON MICHAEL · 2003 to 2022
$7.4M
Protein Structural Dynamics in Living CellsR35GM151146 · NIGMS · YALE UNIVERSITY · PI Caitlin Davis · 2023 to 2026
$1.7M
NIGMS NIH HHS R35 GM151146NIGMS NIH HHS T32 GM067543
6 · The paper itself

Abstract

G-quadruplexes and i-motifs are non-canonical DNA structures that are important not only as targets of gene regulation in cancer therapy, but also as nanotools with biomedical applications. However, their apparent in vitro stabilities and dynamics cast doubt upon their physiological relevance and utility

Identifiers

PMID40631133
PMCPMC12236694

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.