Evidence map›Paper›PMID 40631129›Full record

ArticlebioRxiv : the preprint server for biology2025

Two parallel lineage-committed progenitors contribute to the developing brain.

Carolyn E Dundes, Rayyan T Jokhai, Hadia Ahsan, Rachel S Kang, Rachel E A Salomon-Shulman, Arjun Rajan, Yoon Seok Kim, Liam J Stanton, Christine Xu, Stephanie Do and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Carolyn E DundesDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Rayyan T JokhaiDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Hadia AhsanDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Rachel S KangDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Rachel E A Salomon-ShulmanDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Arjun RajanDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Yoon Seok KimInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University, Stanford, CA USA.
Liam J StantonDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Christine XuDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Stephanie DoDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Brennan D McDonaldHopkins Marine Station, Department of Biology, Stanford University, Pacific Grove, CA USA.
José Miguel Andrade LópezHopkins Marine Station, Department of Biology, Stanford University, Pacific Grove, CA USA.
Hugo A UrrutiaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA USA.
Hannah GreenfeldDepartment of Obstetrics, Gynecology and Reproductive Science, Center for Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
Alicia WongDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Yimiao QuDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Andrew S PetkovicDepartment of Developmental Biology, Stanford University, Stanford, CA USA.
Yi MiaoDepartment of Molecular and Cellular Physiology, Department of Structural Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
K Christopher GarciaDepartment of Molecular and Cellular Physiology, Department of Structural Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9273-0278
Michelle MonjeInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University, Stanford, CA USA.
Daniel E WagnerDepartment of Obstetrics, Gynecology and Reproductive Science, Center for Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
Marianne E BronnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA USA.ORCID 0000-0003-4274-1862
Christopher J LoweHopkins Marine Station, Department of Biology, Stanford University, Pacific Grove, CA USA.
Kyle M LohDepartment of Developmental Biology, Stanford University, Stanford, CA USA.ORCID 0000-0002-8042-0149

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI HASSAN CHAIB · 2017 to 2026
$19.5M
GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
Cell lineage and transcriptional analysis of the vertebrate neural plate borderR01DE027538 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Marianne Bronner · 2018 to 2026
$4.4M
Structure-based Bioengineering of Wnt Surrogates for Intestinal Stem Cell Biology and TherapyR01DK115728 · NIDDK · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER, KUO, CALVIN J · 2018 to 2022
$3.9M
Genetics and Developmental Biology Training ProgramT32GM141828 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER, Gavin J Sherlock · 2022 to 2026
$2.6M
Mapping cell fate flow and feedback control on vertebrate embryonic landscapesDP2GM146258 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAGNER, DANIEL E · 2021 to 2024
$2.3M
Graduate Training in Stem Cell Biology and Regenerative MedicineT32GM119995 · NIGMS · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2017 to 2021
$2.0M
Developing approaches for universal organ transplantationDP5OD024558 · OD · STANFORD UNIVERSITY · PI LOH, KYLE M · 2017 to 2021
$2.0M
Mapping vertebrate differentiation hierarchies with high-throughput single cell transcriptomicsR00GM121852 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAGNER, DANIEL E · 2020 to 2022
$747k
Molecular mechanisms driving cessation of neural crest migration and aggregation into cranial gangliaF31DE031154 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI URRUTIA, HUGO ALEXANDER · 2021 to 2025
$193k
NIDCR NIH HHS F31 DE031154NIDCR NIH HHS R01 DE027538NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK115728NIGMS NIH HHS DP2 GM146258NIGMS NIH HHS R00 GM121852NIGMS NIH HHS T32 GM007365NIGMS NIH HHS T32 GM007790NIGMS NIH HHS T32 GM119995NIGMS NIH HHS T32 GM141828NIH HHS DP5 OD024558
6 · The paper itself

Abstract

The hindbrain is a life-sustaining brain region. In one model, a common neural progenitor generates all brain regions. Here our studies of mouse embryos and human pluripotent stem cells (hPSCs) support a different model: two parallel brain progenitors emerge simultaneously during gastrulation, anterior neural ectoderm (forebrain/midbrain progenitor) and posterior neural ectoderm (hindbrain progenitor). Not only are they lineage-committed to respectively form forebrain/midbrain vs. hindbrain

Identifiers

PMID40631129
PMCPMC12236623

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.