ArticlebioRxiv : the preprint server for biology2025
Engineering Versatile Two-Dimensional Nanobody-Origami Architectures for Enhanced Antiviral Activity.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Considering the serious global health burden posed by pathogenic viruses, the development of effective antiviral molecules and therapeutic strategies is critical for improving human health. Designing and synthesizing a versatile and biocompatible molecular platform offering neutralization of both coronaviruses and retroviruses, two virus families that are greatly problematic to the human population, remains a significant challenge. Here, we report a programmable and versatile platform built on a two-dimensional (2D) DNA origami that enables nanoscale spatial control of multivalent nanobody (Nb) patterns for a broad-spectrum antiviral application. By site-selectively conjugating a Nb to a DNA oligonucleotide and placing multiple of them to predefined sites on 2D DNA origami, we synthesized hybrid nano-architectures with tunable Nb patterns designed to approximately match the geometric presentation of viral surface proteins. We demonstrate that such specific Nb spatial configurations significantly enhance both viral binding affinity and neutralization potency. For SARS-CoV-2, a coronavirus, a triangular Nb pattern with matched spacing with the spike proteins achieved an IC
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