Evidence map›Paper›PMID 40631088›Full record

ArticlebioRxiv : the preprint server for biology2025

De novo design of high-affinity miniprotein binders targeting

Gizem Gokce-Alpkilic, Buwei Huang, Andi Liu, Lieselotte S M Kreuk, Yaxi Wang, Victor Adebomi, Yensi Flores Bueso, Asim K Bera, Alex Kang, Stacey R Gerben and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Gizem Gokce-AlpkilicMolecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5009-4429
Buwei HuangInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Andi LiuDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Lieselotte S M KreukDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Yaxi WangDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Victor AdebomiDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Yensi Flores BuesoInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Asim K BeraInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Alex KangInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Stacey R GerbenInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Stephen RettieDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Dionne K VafeadosInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Nicole RoullierInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Inna GoreshnikInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Xinting LiInstitute for Protein Design, University of Washington, Seattle, WA, USA.
David BakerInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Joshua J WoodwardDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Joseph D MougousDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Gaurav BhardwajMolecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA.

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
De Novo Design of Minibinder Antagonists for COVID-19 and Future PandemicsR01AI160052 · NIAID · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID, FULLER, DEBORAH H. · 2021 to 2025
$3.5M
NIAID NIH HHS R01 AI160052NIGMS NIH HHS P30 GM133893
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40631088
PMCPMC12236611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.