Evidence map›Paper›PMID 40631082›Full record

ArticlebioRxiv : the preprint server for biology2025

Cholinergic Signaling Modulates Intestinal Pathophysiology in a

Elizabeth Lane, Afroditi Petsakou, Ying Liu, Weihang Chen, Mujeeb Qadiri, Yanhui Hu, Norbert Perrimon

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Elizabeth LaneDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 7 02115, USA.
Afroditi PetsakouDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 7 02115, USA.ORCID 0000-0002-9612-5929
Ying LiuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 7 02115, USA.
Weihang ChenDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 7 02115, USA.
Mujeeb QadiriDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 7 02115, USA.ORCID 0009-0006-9697-6447
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 7 02115, USA.ORCID 0000-0003-1494-1402
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 7 02115, USA.ORCID 0000-0001-7542-472X

Funding

Drosophila as a model to study modifiers of Cystic FibrosisF32DK130290 · NIDDK · HARVARD MEDICAL SCHOOL · PI LANE, ELIZABETH · 2021 to 2024
$225k
NIDDK NIH HHS F32 DK130290
6 · The paper itself

Abstract

Cystic Fibrosis (CF) is a monogenic genetic disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride/bicarbonate channel, which is expressed in certain epithelia cells. Current therapies focus on restoring CFTR function but many gut-related pathologies persist, highlighting the need for complementary treatments to improve the quality of life of patients living with CF. In this study, we use

Identifiers

PMID40631082
PMCPMC12236621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.